Yy1 gene dosage effect and bi-allelic expression of Peg3

PloS One
Bambarendage P U PereraJoomyeong Kim

Abstract

In the current study, we tested the in vivo effects of Yy1 gene dosage on the Peg3 imprinted domain with various breeding schemes utilizing two sets of mutant alleles. The results indicated that a half dosage of Yy1 coincides with the up-regulation of Peg3 and Zim1, suggesting a repressor role of Yy1 in this imprinted domain. This repressor role of Yy1 is consistent with the observations derived from previous in vitro studies. The current study also provided an unexpected observation that the maternal allele of Peg3 is also normally expressed, and thus the expression of Peg3 is bi-allelic in the specific areas of the brain, including the choroid plexus, the PVN (Paraventricular Nucleus) and the SON (Supraoptic Nucleus) of the hypothalamus. The exact roles of the maternal allele of Peg3 in these cell types are currently unknown, but this new finding confirms the previous prediction that the maternal allele may be functional in specific cell types based on the lethality associated with the homozygotes for several mutant alleles of the Peg3 locus. Overall, these results confirm the repressor role of Yy1 in the Peg3 domain and also provide a new insight regarding the bi-allelic expression of Peg3 in mouse brain.

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Citations

Oct 29, 2015·Epigenetics : Official Journal of the DNA Methylation Society·Corey L BretzJoomyeong Kim
Apr 15, 2016·Scientific Reports·Bambarendage P U Perera, Joomyeong Kim
Sep 8, 2016·Nucleic Acids Research·Nikolay TsanovFlorian Mueller
Aug 15, 2018·PloS One·Wesley D FreyJoomyeong Kim
Dec 23, 2015·PloS One·Suman LeeJoomyeong Kim
Oct 23, 2019·PloS One·Joomyeong KimLisa Stubbs
May 18, 2016·PLoS Genetics·Anne-Lyse DenizotDavid A Sassoon
Jul 19, 2017·PloS One·Joomyeong KimHana Kim
Aug 4, 2019·Proceedings of the National Academy of Sciences of the United States of America·Ali SeifinejadMehdi Tafti
Jul 27, 2017·Scientific Reports·Hongzhi HeJoomyeong Kim

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Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

ImageJ
COBRA

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