YY1 regulates melanocyte development and function by cooperating with MITF.

PLoS Genetics
Juying LiDavid E Fisher

Abstract

Studies of coat color mutants have greatly contributed to the discovery of genes that regulate melanocyte development and function. Here, we generated Yy1 conditional knockout mice in the melanocyte-lineage and observed profound melanocyte deficiency and premature gray hair, similar to the loss of melanocytes in human piebaldism and Waardenburg syndrome. Although YY1 is a ubiquitous transcription factor, YY1 interacts with M-MITF, the Waardenburg Syndrome IIA gene and a master transcriptional regulator of melanocytes. YY1 cooperates with M-MITF in regulating the expression of piebaldism gene KIT and multiple additional pigmentation genes. Moreover, ChIP-seq identified genome-wide YY1 targets in the melanocyte lineage. These studies mechanistically link genes implicated in human conditions of melanocyte deficiency and reveal how a ubiquitous factor (YY1) gains lineage-specific functions by co-regulating gene expression with a lineage-restricted factor (M-MITF)-a general mechanism which may confer tissue-specific gene expression in multiple lineages.

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Citations

Apr 8, 2014·PloS One·Félix-Antoine Bérubé-SimardLucie Jeannotte
Feb 19, 2013·Future Oncology·Dana Koludrovic, Irwin Davidson
Feb 16, 2013·Database : the Journal of Biological Databases and Curation·Andy M GuoHao Sun
Jun 14, 2013·Cellular and Molecular Life Sciences : CMLS·Shengjuan WeiMichael V Dodson
Apr 25, 2014·The Journal of Investigative Dermatology·Hongxiang ChenDavid E Fisher
Mar 13, 2013·Cancer Cell·Rizwan HaqHans R Widlund
Mar 7, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Akinori Kawakami, David E Fisher
Jan 1, 2016·Biologie aujourd'hui·Patrick LauretteIrwin Davidson
Jun 27, 2017·Pigment Cell & Melanoma Research·Hannah E SebergRobert A Cornell
Jan 22, 2019·Nature Communications·Kaustubh AdhikariAndrés Ruiz-Linares
Nov 12, 2019·EMBO Reports·Desingu Ayyappa RajaVivek T Natarajan
Dec 13, 2017·Experimental Dermatology·Kaiyuan JiChangsheng Dong
Feb 22, 2018·Cell Death and Differentiation·Archis BagatiMikhail A Nikiforov
Apr 10, 2020·Cancer Discovery·Shinichiro KatoDavid E Fisher
Mar 18, 2021·Stem Cell Reviews and Reports·Gustavo Ulises Martinez-RuizAngel Francisco Pacheco-Hernandez
Jun 9, 2021·Life Science Alliance·Gang PanClaes Wadelius

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Methods Mentioned

BETA
RSA
ChIP
ChIP-seq
genotyping
dissection
PCR
transfection
immunoprecipitation
scraping

Software Mentioned

Illumina Genome Analyzer II
AxioVision
TRANSFAC
Fast System SDS
MACS
RefSeq
RSA
7500
JASPAR
RMA

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