YYFZBJS ameliorates colorectal cancer progression in ApcMin/+ mice by remodeling gut microbiota and inhibiting regulatory T-cell generation.

Cell Communication and Signaling : CCS
Hua SuiQi Li

Abstract

Progression of Colorectal cancer (CRC) is influenced by single or compounded environmental factors. Accumulating evidence shows that microbiota can influence the outcome of cancer immunotherapy. T cell, one of the main populations of effector immune cells in antitumor immunity, has been considered as a double-edged sword during the progression of CRC. Our previous studies indicate that traditional Chinese herbs (TCM) have potential anticancer effects in improving quality of life and therapeutic effect. However, little is known about the mechanism of TCM formula in cancer prevention. Here, we used C57BL/6 J ApcMin/+ mice, an animal model of human intestinal tumorigenesis, to investigate the gut bacterial diversity and their mechanisms of action in gastrointestinal adenomas, and to evaluate the effects of Yi-Yi-Fu-Zi-Bai-Jiang-San (YYFZBJS) on of colon carcinogenesis in vivo and in vitro. Through human-into-mice fecal microbiota transplantation (FMT) experiments from YYFZBJS volunteers or control donors, we were able to differentially modulate the tumor microbiome and affect tumor growth as well as tumor immune infiltration. We report herein, YYFZBJS treatment blocked tumor initiation and progression in ApcMin/+ mice with less ch...Continue Reading

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Citations

Feb 23, 2021·Therapeutic Advances in Infectious Disease·Simon D Goldenberg, Blair Merrick
Feb 25, 2021·The American Journal of Chinese Medicine·Xiao LiHaixue Kuang
Apr 9, 2021·The American Journal of Chinese Medicine·Hui ZhaoHaibo Xu

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Methods Mentioned

BETA
PCR
RNA-Seq
ELISA
antibody array
flow cytometry

Software Mentioned

Array Vision Evaluation
Cytoscape
FLASH ( Fast Length Adjustment of Short
CLC Genomics Workbench

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