(Z)-3,5,4'-Tri-O-methyl-resveratrol, induces apoptosis in human lymphoblastoid cells independently of their p53 status

Cancer Letters
Yann SchneiderFrancis Raul

Abstract

The pro-apoptotic ability of (Z)-3,5,4'-Tri-O-methyl-resveratrol (R3) was investigated in vitro on the human lymphoblastoid cell line TK6 and its p53-knockout counterpart (NH32). In both cell lines, R3 induced the stimulation of caspase-3. Although R3 induced growth inhibition and apoptosis of both cell lines, two distinct mechanisms were observed. The p53-knockout NH32 cells were shown to override the G2/M phase checkpoint with development of hyperdiploid cells, whereas TK6 cells accumulated at G2/M. As p53 function is often altered in human cancer cells, these results show that the pro-apototic effects of R3 against tumor cells are independent of their p53 status.

References

Mar 1, 1997·Clinical Biochemistry·G J SoleasD M Goldberg
Jan 13, 1998·Current Opinion in Cell Biology·P K SorgerA A Hyman
Sep 29, 1999·Cancer Chemotherapy and Pharmacology·L G WangD R Budman
Jun 21, 2002·Annals of the New York Academy of Sciences·Krishna P L Bhat, John M Pezzuto
Sep 2, 2003·International Journal of Cancer. Journal International Du Cancer·Yann SchneiderFrancis Raul

❮ Previous
Next ❯

Citations

Sep 14, 2010·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Kashif AliRobert Verpoorte

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis