(Z)-7,4'-Dimethoxy-6-hydroxy-aurone- 4-O-β-glucopyranoside alleviates cerebral ischemia-reperfusion injury in rats associating with the regulation of JAK1/STAT1 signaling pathway.

Human & Experimental Toxicology
R DuQ Li

Abstract

Inflammatory responses have been demonstrated to contribute to the neuronal death following cerebral ischemia. This study was to investigate the repairing effects and potential mechanisms of (Z)-7,4'-dimethoxy-6-hydroxy-aurone-4-O-β-glucopyranoside (DHAG), a compound with neuroprotective effects, on cerebral ischemia-reperfusion (I/R) injury in rats. Cerebral I/R model was established with middle cerebral artery occlusion method in Sprague Dawley rats and then rats were treated with DHAG (1 and 2 mg/kg) for 7 days. The volume of cerebral infarction was detected by triphenyltetrazolium chloride staining. The apoptosis in ischemic brain tissues was detected by terminal deoxynucleotidyl transferase dUTP nick end labeling assay. Oxidative stress markers and inflammatory factors were detected by enzyme-linked immunosorbent assay. Protein expression was detected by Western blot. DHAG treatment significantly alleviated the cerebral I/R injury and decreased apoptosis in brain tissues. Moreover, DHAG treatment significantly inhibited oxidative stress and reduced inflammatory responses, associating with decreasing the protein expression of phosphorylated Janus kinase 1/phosphorylated signal transducer and transcriptional activator 1. The...Continue Reading

References

May 1, 1986·Stroke; a Journal of Cerebral Circulation·J B BedersonH Bartkowski
Mar 5, 2002·Nature Immunology·Michael Karin, Anning Lin
Aug 5, 2006·Advances in Enzyme Regulation·Makoto Kobayashi, Masayuki Yamamoto
Aug 10, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Richard K Monroe, Stanley W Halvorsen
Sep 27, 2006·Biochemical and Biophysical Research Communications·Jing Chen-Roetling, Raymond F Regan
Oct 5, 2006·Current Alzheimer Research·Isaac G Onyango, Shaharyar M Khan
Jan 24, 2007·Physiological Reviews·Karen Bedard, Karl-Heinz Krause
May 11, 2007·Brain Research·Alexsandro da Silva HaeserCarmen Regla Vargas
Feb 1, 2008·Inflammopharmacology·J N SharmaS S Parvathy
Aug 2, 2008·PPAR Research·John J BrightSharmistha Chakraborty
Nov 18, 2008·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Andrey G SarafanovJosé A Centeno
Mar 5, 2010·Current Drug Targets·Kenneth B MarcuMary B Goldring
May 8, 2010·Antioxidants & Redox Signaling·Ken ItohMasayuki Yamamoto
May 12, 2010·Cold Spring Harbor Perspectives in Biology·Toby Lawrence
May 25, 2010·FEBS Letters·Jingsong YuanJunjie Chen
Dec 17, 2010·Circulation·Véronique L RogerUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Jan 7, 2014·Journal of Experimental & Clinical Cancer Research : CR·Xiaofei ZhaoLing Su
Aug 13, 2014·Molecular and Cellular Biology·Gordon P MearesEtty N Benveniste
Jul 5, 2017·Journal of Immunological Methods·Lisa SchmölzStefan Lorkowski
Feb 9, 2019·Cellular and Molecular Life Sciences : CMLS·Philipp BerndtReiner F Haseloff
Apr 26, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wenqi JinLiwei Sun

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Methods Mentioned

BETA
dissection
enzyme-linked immunosorbent assay
X-ray
MDA

Software Mentioned

SPSS

Related Concepts

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis