Z-drugs and risk for falls and fractures in older adults-a systematic review and meta-analysis

Age and Ageing
Nir TrevesIlan Matok

Abstract

zolpidem, zopiclone, eszopiclone and zaleplon, also known as 'Z-drugs', are commonly used as alternatives to benzodiazepines (BZDs) to treat insomnia. Z-drugs are often perceived as safer than BZDs. We conducted a systematic review and meta-analysis evaluating the association between Z-drugs and fracutres, falls and injuries. a systematic review was performed using MEDLINE, EMBASE and ClinicalTials.gov. Pooled effect-sizes were calculated comparing Z-drugs users with non-users, using fixed and random-effect models with corresponding 95% confidence of intervals (CI). we identified 14 eligible studies reporting on the association between Z-drugs and outcomes of interest. Z-Drugs were associated with a statistically significant increased risk for fractures, with evidence of considerable heterogeneity (OR = 1.63; 95% CI: 1.42-1.87; I2 = 90%; n = 830,877). Likewise, there was a trend suggesting a 2-fold increase in the odds for falls, however, this result was not statistically significant and there was evidence of considerable heterogeneity (OR = 2.40; 95% CI: 0.92-6.27; I2 = 95%; n = 19,505). In an analysis assessing the risk for injuries following exposure to zolpidem we found a statistically significant increased risk of injuries...Continue Reading

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Citations

Jan 11, 2019·Journal of the American Geriatrics Society·Julie H IshidaKirsten L Johansen
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Jul 3, 2021·Clinics in Geriatric Medicine·Becky X Lou, Margarita Oks
May 6, 2021·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Mumtaz BegumNigel Stocks
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Jan 14, 2019··Carsten RudolphTharuka Rupasinghe

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