Z-Spectrum analysis provides proton environment data (ZAPPED): a new two-pool technique for human gray and white matter

PloS One
Mitsue MiyazakiKaori Togashi

Abstract

A new technique - Z-spectrum Analysis Provides Proton Environment Data (ZAPPED) - was used to map cross-relaxing free and restricted protons in nine healthy subjects plus two brain tumor patients at 3T. First, MT data were acquired over a wide symmetric range of frequency offsets, and then a trio of quantitative biomarkers, i.e., the apparent spin-spin relaxation times (T2,f, T2,r) in both free and restricted proton pools as well as the restricted pool fraction Fr, were mapped by fitting the measured Z-spectra to a simple two-Lorentzian compartment model on a voxel-by-voxel basis. The mean restricted exchangeable proton fraction, Fr, was found to be 0.17 in gray matter (GM) and 0.28 in white matter (WM) in healthy subjects. Corresponding mean values for apparent spin-spin relaxation times were 785 µs (T2,f) and 17.7 µs (T2,r) in GM, 672 µs (T2,f) and 23.4 µs (T2,r) in WM. The percentages of Ff and Fr in GM are similar for all ages, whereas Fr shows a tendency to decrease with age in WM among healthy subjects. The patient ZAPPED images show higher contrast between tumor and normal tissues than traditional T2-weighted and T1-weighted images. The ZAPPED method provides a simple phenomenological approach to estimating fractions and...Continue Reading

References

Jun 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G B PikeD R Enzmann
Aug 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S H Koenig
Jun 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S H KoenigN Lundbom
Apr 1, 1989·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S D Wolff, R S Balaban
Jul 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M MiyazakiH Igarashi
May 5, 1998·Neurology·C R GuttmannM S Albert
Jun 22, 2000·NeuroImage·J Ashburner, K J Friston
Oct 25, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J G Sled, G B Pike
Apr 18, 2002·Neurobiology of Aging·Osamu AbeKuni Ohtomo
Apr 30, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Vasily L Yarnykh
Aug 9, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Greg J StaniszR Mark Henkelman
Feb 22, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peter C M van Zijl, Nirbhay N Yadav
Mar 26, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M SoellingerS Ropele
Dec 23, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Vasily L Yarnykh

❮ Previous
Next ❯

Citations

Jun 2, 2018·Contrast Media & Molecular Imaging·Kazufumi KikuchiMasaya Takahashi

❮ Previous
Next ❯

Software Mentioned

ZAPPED
- spectrum Analysis Provides Proton Environment Data ( ZAPPED )
MATLAB
SPM

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Related Papers

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
I LevesqueG Bruce Pike
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
D J TozerP S Tofts
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Jun HuaJinyuan Zhou
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
J G Sled, G B Pike
© 2021 Meta ULC. All rights reserved