Zanthoxylum bungeanum Maxim. (Rutaceae): A Systematic Review of Its Traditional Uses, Botany, Phytochemistry, Pharmacology, Pharmacokinetics, and Toxicology

International Journal of Molecular Sciences
Mengmeng ZhangChunjie Wu

Abstract

Zanthoxylum bungeanum Maxim. (Rutaceae) is a popular food additive and traditional Chinese herbal medicine commonly named HuaJiao in China. This plant is widely distributed in Asian countries. The aim of this paper is to provide a systematic review on the traditional usages, botany, phytochemistry, pharmacology, pharmacokinetics, and toxicology of this plant. Furthermore, the possible development and perspectives for future research on this plant are also discussed. To date, over 140 compounds have been isolated and identified from Z. bungeanum, including alkaloids, terpenoids, flavonoids, and free fatty acids. The extracts and compounds have been shown to possess wide-ranging biological activity, such as anti-inflammatory and analgesic effects, antioxidant and anti-tumor effects, antibacterial and antifungal effects, as well as regulatory effects on the gastrointestinal system and nervous system, and other effects. As a traditional herbal medicine, Z. bungeanum has been widely used to treat many diseases, especially digestive disorders, toothache, stomach ache, and diarrhea. Many traditional usages of this plant have been validated by present investigations. However, further research elucidating the structure-function relation...Continue Reading

References

Sep 5, 2007·The European Journal of Neuroscience·Jae Yeon KooUhtaek Oh
Aug 8, 2008·Journal of Agricultural and Food Chemistry·Fang-Xia YangRun-Cang Sun
Feb 3, 2011·International Journal of Cosmetic Science·C ArtariaG Appendino
Nov 29, 2012·Journal of Alzheimer's Disease : JAD·Maoping TangZhongdong Qiao
May 9, 2013·The Journal of Physiology·Makoto TsunozakiDiana M Bautista
Apr 25, 2014·Pesticide Biochemistry and Physiology·Xinke TangLianyang Bai
Aug 12, 2014·International Journal of Biological Macromolecules·Peiqin LiZiling Mao
Sep 26, 2014·BMC Complementary and Alternative Medicine·Qian YangSiwang Wang
Jan 31, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kunitsugu KubotaYasuhito Uezono
Apr 4, 2015·Journal of Pharmacological Sciences·Tingting WuYizhun Zhu
Dec 29, 2015·Bioorganic & Medicinal Chemistry Letters·Jun-Mian TianJin-Ming Gao
Apr 5, 2016·Journal of Ethnopharmacology·Keyou LiTiancun Xiao
May 29, 2016·Journal of Separation Science·Rong RongYun-Li Zhao
Oct 27, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuan WangJin-Ming Gao

Citations

May 9, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xi ChenChunjie Wu
May 6, 2020·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Yixuan LiChunze Zhang
Oct 31, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Aleksandra ShedoevaChen Fan
Jul 6, 2019·Food Science and Biotechnology·Wenlin ZhangJianmin Tang
Aug 25, 2020·International Journal of Analytical Chemistry·Hyeon Seok JangHeejung Yang

Related Concepts

Metazoa
Plant Extracts, Chinese
Xanthoxylum inerme
Antioxidants
Digestive System Disorders
Pharmaceutical Preparations
Fatty Acids
Drug Kinetics
Pharmacology
Physiological Aspects

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