Zanthoxylum piperitum reversed alveolar bone loss of periodontitis via regulation of bone remodeling-related factors

Journal of Ethnopharmacology
Mi Hye KimWoong Mo Yang


Zanthoxylum piperitum (ZP) has been used to prevent toothache in East Asia. In this study, we investigated the effects of ZP on periodontitis along with alveolar bone loss. Twenty-eight male Sprague-Dawley rats were assigned into 4 groups; non-ligated (NOR), ligated and treated vehicle (CTR), ligated and treated 1mg/mL ZP (ZP1), and ligated and treated 100mg/mL ZP (ZP100). Sterilized 3-0 nylon ligature was placed into the subgingival sulcus around the both sides of mandibular first molar. After topical application of 1 and 100mg/mL ZP for 2 weeks, mandibles was removed for histology. In addition, SaOS-2 osteoblast cells were treated 1, 10 and 100μg/mL ZP for 24h to analyze the expressions of alveolar bone-related markers. Several alveolar bone resorption pits, which indicate cementum demineralization were decreased by ZP treatment. Topical ZP treatment inhibited periodontitis-induced alveolar bone loss. In addition, there were significant reduction of osteoclastic activities following topical ZP treatment in periodontium. The expression of RANKL was decreased in SaOS-2 osteoblast cells by treating ZP, while that of OPG was increased. ZP treatment increased the expressions of Runx2 and Osterix in SaOS-2 cells. In summary, ZP tre...Continue Reading


Nov 15, 2000·Fitoterapia·M AhsanS K Islam
Jul 11, 2002·Oral Diseases·T Katagiri, N Takahashi
Mar 11, 2004·Journal of Periodontal Research·A KuhrT Kocher
Sep 6, 2005·Bioorganic & Medicinal Chemistry·Ming-Jen ChengIh-Sheng Chen
Aug 22, 2008·Periodontology 2000·Philip M Preshaw
Feb 14, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·S-J Lee, K-T Lim
Apr 28, 2009·Current Opinion in Nephrology and Hypertension·Koichi Matsuo
Apr 21, 2010·Periodontology 2000·P Mark BartoldDavid Haynes
May 7, 2011·Journal of Oral Microbiology·Dana T GravesGustavo Pompermaier Garlet
Aug 7, 2012·Archives of Pharmacal Research·Cholpisut TantapakulSurat Laphookhieo
Oct 16, 2012·Journal of Pharmacy & Bioallied Sciences·Sugumari ElavarasuThamaraiselvan Murugan
Sep 5, 2015·Journal of Periodontal & Implant Science·Mi Hye KimWoong Mo Yang


Jul 7, 2017·Mediators of Inflammation·Jae Gwang ParkJae Youl Cho
Oct 10, 2019·Tissue Engineering. Part B, Reviews·Bing WangFang Yang
Nov 2, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Mi Hye KimWoong Mo Yang

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