Zanthoxylum schinifolium leaf ethanol extract inhibits adipocyte differentiation through inactivation of the extracellular signal regulated kinase and phosphoinositide 3-kinase/Akt signaling pathways in 3T3-L1 pre-adipocytes

Molecular Medicine Reports
Eun-Ok ChoiYung Hyun Choi

Abstract

Zanthoxylum schinifolium is widely used as a food flavoring in east Asia. Although this plant has also been used in traditional oriental medicine for the treatment of the common cold, toothache, stomach ache, diarrhea and jaundice, its anti-obesity activity remains to be elucidated. The present study investigated the effects of ethanol extract from the leaves of Z. schinifolium (EEZS) on adipocyte differentiation, and its underlying mechanism, in 3T3-L1 pre-adipocytes. The results demonstrated that EEZS effectively suppressed intracellular lipid accumulation at non-toxic concentrations, and was associated with the downregulation of several adipocyte-specific transcription factors, including peroxisome proliferation-activity receptor γ (PPARγ), CCAAT/enhancer binding protein (C/EBP)α and C/EBPβ, in a concentration-dependent manner. Furthermore, it was observed that EEZS markedly inactivated the extracellular signal-regulated protein kinase (ERK) and phosphatidylinositide 3-kinase (PI3K)/Akt pathways, which act upstream of PPARγ and C/EBPs in adipogenesis. These results suggested that EEZS inhibited lipid accumulation by downregulating the major transcription factors involved in the pathway of adipogenesis, including PPARγ, C/EBP...Continue Reading

References

Jan 1, 1994·Annual Review of Nutrition·P CorneliusM D Lane
Apr 15, 2000·Nature·P G Kopelman
Apr 15, 2000·Nature·G A Bray, L A Tartaglia
Jan 4, 2001·The Journal of Nutrition·J M Ntambi, K Young-Cheul
Jul 11, 2001·The Journal of Biological Chemistry·A SoukasJ M Friedman
Dec 1, 2001·Reviews in Endocrine & Metabolic Disorders·Q Tong, G S Hotamisligil
Feb 14, 2002·Planta medica·Young Su JoYoung Ho Kim
Jul 18, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·D Thompson, A M Wolf
Mar 1, 2005·Biochimie·F BostB Binétruy
Jun 7, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Evan D Rosen
Oct 29, 2005·Journal of Periodontology·Caroline Formolo Dalla VecchiaJasim M Albandar
Dec 2, 2006·Nature Reviews. Molecular Cell Biology·Evan D Rosen, Ormond A MacDougald
Apr 25, 2007·Journal of Dental Research·N PischonT Pischon
Dec 6, 2008·The Journal of Nutrition·Harumi Uto-KondoKazuo Kondo
Mar 28, 2009·Gastroenterology·Elizabeth K Speliotes
Apr 29, 2009·Nature Reviews. Cardiology·Viviane Z Rocha, Peter Libby
Jul 14, 2009·PloS One·Hui H ZhangBrendan D Manning
Nov 9, 2010·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·T TzotzasD N Kiortsis
Dec 15, 2010·The New England Journal of Medicine·Mark I McCarthy
Aug 13, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J A N DorresteijnW Spiering
Aug 23, 2011·The Medical Clinics of North America·Remco FranssenJohn J P Kastelein
Sep 14, 2011·Expert Opinion on Biological Therapy·Charmaine S TamEric Ravussin
Jan 12, 2013·Experimental & Molecular Medicine·Mi-Young KimMyoung-Sool Do
Aug 8, 2013·Nature Medicine·Clare M Lloyd, Sejal Saglani
Oct 23, 2013·Journal of Agricultural and Food Chemistry·Wei LiYoung Ho Kim
Mar 13, 2014·Nutrition Research and Practice·Jin RhyuHyeon-A Kim

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