ZapA, a virulence factor in a rat model of Proteus mirabilis-induced acute and chronic prostatitis.

Infection and Immunity
Van PhanHoward Ceri

Abstract

Our knowledge of pathogenesis has benefited from a better understanding of the roles of specific virulence factors in disease. To determine the role of the virulence factor ZapA, a 54-kDa metalloproteinase of Proteus mirabilis, in prostatitis, rats were infected with either wild-type (WT) P. mirabilis or its isogenic ZapA(-) mutant KW360. The WT produced both acute and chronic prostatitis showing the typical histological progressions that are the hallmarks of these diseases. Infection with the ZapA(-) mutant, however, resulted in reduced levels of acute prostatitis, as determined from lower levels of tissue damage, bacterial colonization, and inflammation. Further, the ZapA(-) mutant failed to establish a chronic infection, in that bacteria were cleared from the prostate, inflammation was resolved, and tissue was seen to be healing. Clearance from the prostate was not the result of a reduced capacity of the ZapA(-) mutant to form biofilms in vitro. These finding clearly define ZapA as an important virulence factor in both acute and chronic bacterial prostatitis.

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Citations

Dec 18, 2010·Chemical Reviews·Karine A Gibbs, E Peter Greenberg
Jul 14, 2010·Journal of Bacteriology·Eleonora AquiliniMiguel Regué
Jan 1, 2013·Pathogens·David LebeauxChristophe Beloin
Feb 10, 2021·Infection and Immunity·Von Vergel L TorresTimothy J Wells
Feb 10, 2018·EcoSal Plus·Chelsie E ArmbrusterMelanie M Pearson
Nov 7, 2015·Microbiology Spectrum·Jessica N Schaffer, Melanie M Pearson

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