ZBP-89, a Krüppel-like zinc finger protein, inhibits epidermal growth factor induction of the gastrin promoter.

Molecular and Cellular Biology
J L MerchantR Bassel-Duby

Abstract

We have shown previously that a GC-rich element (GGGGCGGGGTGGGGGG) conferring epidermal growth factor (EGF) responsiveness to the human gastrin promoter binds Sp1 and additional undefined complexes. A rat GH4 cell line expression library was screened by using a multimer of the gastrin EGF response element, and three overlapping cDNA clones were identified. The full-length rat cDNA encoded an 89-kDa zinc finger protein (ZBP-89) that was 89% identical to a 49-kDa human factor, ht(beta), that binds a GTGGG/CACCC element in T-cell receptor promoters. The conservation of amino acids between the zinc fingers indicates that ZBP-89 is a member of the C2H2 zinc finger family subclass typified by the Drosophila Krüppel protein. ZBP-89 is ubiquitously expressed in normal adult tissues. It binds specifically to the gastrin EGF response element and inhibits EGF induction of the gastrin promoter. Collectively, these results demonstrate that ZBP-89 functions as a repressor of basal and inducible expression of the gastrin gene.

References

Dec 30, 1992·Biochemical and Biophysical Research Communications·Y KitadaiE Tahara
Aug 25, 1992·Proceedings of the National Academy of Sciences of the United States of America·C SchindlerJ E Darnell
May 1, 1992·Molecular and Cellular Biology·R M Attar, M Z Gilman
Dec 1, 1991·Trends in Biochemical Sciences·C Dingwall, R A Laskey
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S L AckermanC Y Yeung
Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·P BrayI B Dawid
Feb 1, 1990·Molecular and Cellular Biology·K W Kinzler, B Vogelstein
Nov 3, 1989·Cell·M Levine, J L Manley
Jan 1, 1983·Annals of Internal Medicine·R T JensenM J Collen
Mar 17, 1995·The Journal of Biological Chemistry·Y WuG F Saunders
Mar 17, 1995·The Journal of Biological Chemistry·J L MerchantD R Abraczinskas
Jun 11, 1993·Annals of the New York Academy of Sciences·S L Madden, F J Rauscher

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Citations

Jul 30, 2010·Journal of Neurochemistry·Sandra P BuiraMarta Barrachina
Feb 24, 2009·Biochimica Et Biophysica Acta·Morgan SalmonZendra E Zehner
Sep 21, 2010·Biochimica Et Biophysica Acta·Ann K Y ToPaul B S Lai
Feb 22, 2001·Annual Review of Physiology·G J DockrayT Wang
Sep 6, 2005·Biochemical and Biophysical Research Communications·Abhijit ChakladarTimothy C Wang
Jul 10, 2004·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Brendan C StackChristopher S Hollenbeak
Mar 9, 2004·Biochemical and Biophysical Research Communications·Ruth C BorghaeiJoanna Woloshin
May 12, 2000·Alimentary Pharmacology & Therapeutics·S SzaboM Yoshida
Sep 26, 2013·The American Journal of Gastroenterology·Helmut GrasbergerJuanita L Merchant
Aug 26, 2018·Expert Opinion on Therapeutic Targets·Nuozhou WangGeorge G Chen
Nov 25, 2004·The Journal of Biological Chemistry·John D NotiJill D Dillon
Mar 30, 2001·The Journal of Biological Chemistry·A YamadaK Takatsu
Oct 5, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·David J LawJuanita L Merchant
Aug 1, 2007·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yongzhong WuZendra E Zehner
May 23, 2008·Molecular Biology Reports·Isidora PetrovicMilena Stevanovic
Feb 14, 2004·Cell Death and Differentiation·L BaiJ L Merchant
Nov 28, 2006·Nature Reviews. Cancer·Susan A WatsonArjun Takhar
Dec 31, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Madhu S MaloRichard A Hodin
Jul 26, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Aparajita DasVijay Boggaram
Feb 11, 2015·Molecular Systems Biology·Benjamin A DinerIleana M Cristea
Jul 26, 2019·The Journal of Clinical Investigation·Mark P KellerAlan D Attie
Aug 16, 2017·Scientific Reports·Jesse BakkeTaosheng Chen

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