Dec 14, 2017

ZBP1: Innate Sensor Regulating Cell Death and Inflammation

Trends in Immunology
Teneema Kuriakose, Thirumala-Devi Kanneganti

Abstract

Z-DNA-binding protein 1 (ZBP1), initially reported as an interferon (IFN)-inducible tumor-associated protein, harbors nucleic acid-binding domains for left-handed helix (Z-form) and receptor-interacting protein homotypic interaction motif (RHIM) domains for protein homotypic interactions. Recent studies have identified ZBP1 as an innate sensor of viral infections and a target of viral evasion strategies, regulating cell death, inflammasome activation, and proinflammatory responses. ZBP1 also functions during development and can trigger perinatal lethality when its RHIM-dependent interactions are not restricted. Here we review the history and emergence of ZBP1 as a pathogen sensor and a central regulator of cell death and inflammatory responses. We also discuss the gaps in our knowledge regarding the regulation and functions of ZBP1 and highlight potential avenues for future research.

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Mentioned in this Paper

Study
Research
Immune Evasion
Molecular Helix
Strategy
Systemic Inflammatory Response Syndrome
Virus Diseases
Regulation of Biological Process
Pathogenic Organism
RIP Homotypic Interaction Motif Binding

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