Zbtb20 Regulates Developmental Neurogenesis in the Olfactory Bulb and Gliogenesis After Adult Brain Injury

Molecular Neurobiology
Thorsten R DoeppnerAnastassia Stoykova

Abstract

The transcription factor (TF) Zbtb20 is important for the hippocampal specification and the regulation of neurogenesis of neocortical projection neurons. Herein, we show a critical involvement of the TF Zbtb20 in the neurogenesis of both projection neurons and interneurons of the olfactory bulb during embryonic stages. Our data indicate that the lack of Zbtb20 significantly diminishes the generation of a set of early-born Tbr2+ neurons during embryogenesis. Furthermore, we provide evidence that Zbtb20 regulates the transition between neurogenesis to gliogenesis in cortical radial glial progenitor cells at the perinatal (E18.5) stage. In the adult mammalian brain, Zbtb20 is expressed by GFAP+ neural progenitor cells (NPCs) located in the forebrain neurogenic niche, i.e., the subventricular zone (SVZ) of the lateral ventricles. Upon induction of cerebral ischemia, we found that Zbtb20 expression is upregulated in astrocytic-like cells, whereas diminishing the expression levels of Zbtb20 significantly reduces the ischemia-induced astrocytic reaction as observed in heterozygous Zbtb20 loss-of-function mice. Altogether, these results highlight the important role of the TF Zbtb20 as a temporal regulator of neurogenesis or gliogenesis...Continue Reading

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Citations

Sep 27, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Yangmei ZhangXiang Wang
Aug 28, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·An-Jing RenWeiping J Zhang
Mar 23, 2021·Frontiers in Medicine·Xin JiaLing Zhang
Jul 8, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Fangfang LiQing Li

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Methods Mentioned

BETA
confocal microscopy
Fluorescence
transgenic

Software Mentioned

Leica Advanced Fluorescence
Adobe Photoshop

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