PMID: 8972700Dec 4, 1996Paper

Zeaxanthin (dihydroxy-beta-carotene) but not beta-carotene rigidifies lipid membranes: a 1H-NMR study of carotenoid-egg phosphatidylcholine liposomes

Biochimica Et Biophysica Acta
J Gabrielska, W I Gruszecki

Abstract

1H-NMR technique was applied to study liposomes formed with egg-yolk phosphatidylcholine containing as an additional component two carotenoid pigments: beta-carotene or zeaxanthin (dihydrohy-beta-carotene). A strong rigidifying effect of zeaxanthin but not of beta-carotene with respect to hydrophobic core of lipid bilayer was concluded from the carotenoid-dependent broadening of the NMR lines assigned to -CH2- groups and terminal -CH3 groups of lipid alkyl chains. A similar effect of zeaxanthin with respect to polar headgroups was concluded on the basis of the effect of the pigment on the shape of NMR lines attributed to -N+(CH3)3 groups. In contrast, beta-carotene increases motional freedom of lipid polar headgroups. The inclusion of both carotenoids to liposomes resulted in the enhanced penetration of Pr3+ ions to the polar zone of the external layer of a membrane monitored by the splitting of the -N+(CH3)3 signal, the effect of beta-carotene being much more pronounced. Differences in the effect on membrane structure and molecular dynamics observed for beta-carotene and its polar derivative are discussed in terms of organization of a carotenoid-containing lipid membrane.

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Citations

Mar 19, 2008·European Biophysics Journal : EBJ·A BlaskoM Pesti
Jun 11, 2008·Applied Microbiology and Biotechnology·Nallasamy KumaresanSukumaran Umesh-Kumar
Apr 28, 2005·Chemistry and Physics of Lipids·Małgorzata Jemioła-RzemińskaKazimierz Strzałka
Feb 22, 2003·Biochimica Et Biophysica Acta·Catarina RodriguesBaltazar de Castro
Jan 30, 2014·Nutrients·Joanna Fiedor, Květoslava Burda
Sep 18, 2008·Journal of Nutritional Science and Vitaminology·Kenji Fukuzawa
Feb 11, 2016·The Journal of Membrane Biology·Paulina StrugałaJanina Gabrielska
Apr 29, 2006·FEBS Letters·Janina GabrielskaWiesław I Gruszecki
Apr 29, 2006·Magnetic Resonance in Chemistry : MRC·M L Miglietta, R Lamanna
Jul 13, 2006·Molecular Nutrition & Food Research·Jingli ZhangLaurence D Melton
Oct 31, 2006·Biochimica Et Biophysica Acta·Hyesun P McNultyR Preston Mason
Mar 19, 2014·Magnetic Resonance in Chemistry : MRC·Roksana WałęsaMałgorzata A Broda
Jun 14, 2005·Biochimica Et Biophysica Acta·Agnieszka SujakWiesław I Gruszecki
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Oct 24, 2012·Biochimica Et Biophysica Acta·Bożena Pawlikowska-PawlęgaWiesław I Gruszecki
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Jun 14, 2005·Biochimica Et Biophysica Acta·Wiesław I Gruszecki, Kazimierz Strzałka
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