Zeaxanthin dipalmitate from Lycium chinense fruit reduces experimentally induced hepatic fibrosis in rats

Biological & Pharmaceutical Bulletin
H P KimYoung Choong Kim

Abstract

We previously reported that zeaxanthin dipalmitate (ZD), a carotenoid from Lycium chinense fruit, reduces myofibroblast-like cell proliferation and collagen synthesis in vitro. To determine whether ZD might reduce the severity of hepatic fibrosis in an animal model, hepatic fibrosis was induced in rats by bile duct ligation/scission (BDL) for a period of 6 weeks. Treatment of BDL rats with ZD at a dose of 25 mg/kg body weight significantly reduced the activities of aspartate transaminase (p<0.05) and alkaline phosphatase (p<0.001) in serum. Furthermore, collagen deposition was significantly reduced as assessed by the Sirius Red binding assay in BDL rats administered ZD at the dose of 25 mg/kg body weight (p<0.01). In addition, the levels of thiobarbituric acid-reactive substances and 4-hydroxyproline were reduced when BDL rats received ZD at the dose of 25 mg/kg body weight. These results showed that ZD effectively inhibited hepatic fibrosis in BDL rats, at least in part via its antioxidative activity.

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Citations

May 9, 2009·Digestive Diseases and Sciences·Sherman M ChamberlainManuela Bartoli
Jan 6, 2006·Plant Foods for Human Nutrition·Yong PengZhongzhen Zhao
May 9, 2014·Journal of Dietary Supplements·Catherine UlbrichtSara Zhou
Aug 5, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shicheng ZhaoSang Un Park
Sep 19, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Nisma Lena Bahaji Azami, Mingyu Sun
Jun 16, 2011·Chemistry & Biodiversity·Xia YaoPei-Gen Xiao
Dec 20, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Phil Jun LeeHong Pyo Kim

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