Zebrafish and chicken lipocalin-type prostaglandin D synthase homologues: Conservation of mammalian gene structure and binding ability for lipophilic molecules, and difference in expression profile and enzyme activity

Gene
Ko FujimoriY Urade

Abstract

Lipocalin-type prostaglandin (PG) D synthase (L-PGDS) is a bifunctional protein possessing both the ability to synthesize PGD(2) and to serve as a carrier protein for lipophilic molecules. L-PGDS has been extensively studied in mammalian species, whereas little is known about non-mammalian forms. Here, we identified and characterized the L-PGDS homologues from non-mammals such as zebrafish and chicken. Phylogenetic analysis revealed that L-PGDSs of mammalian and non-mammalian organisms form a "L-PGDS sub-family" that has been evolutionally separated from other lipocalin gene family proteins. The genes for zebrafish and chicken L-PGDS homologues consisted of 6 exons, and all of the exon/intron boundaries were completely identical to those of mammalian L-PGDS genes. Zebrafish and chicken L-PGDS genes were clustered with several lipocalin genes in the chromosome, as in the case of mouse and human genes. Gene expression profiles were different among chicken, mouse, human, except for conservation of abundant expression in the brain and heart. The chicken L-PGDS homologue carried weak PGDS activity, whereas the zebrafish protein did not show any of the activity. However, when the amino-terminal region of the zebrafish L-PGDS homologu...Continue Reading

References

May 17, 1976·European Journal of Biochemistry·U CoganM Shinitzky
Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·M IgarashiO Hayaishi
Jan 1, 1988·Annual Review of Genetics·J Felsenstein
Feb 14, 1984·Biochemical and Biophysical Research Communications·F PanabièresJ M Blanchard
May 5, 1982·Journal of Molecular Biology·J Kyte, R F Doolittle
May 1, 1993·Protein Science : a Publication of the Protein Society·D R FlowerT K Attwood
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·Y UradeO Hayaishi
Nov 1, 1996·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A HoffmannG Gross
May 30, 1997·The Journal of Biological Chemistry·D M WhiteB G Arnason
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·Y EguchiO Hayaishi
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·N EguchiO Hayaishi
Jul 20, 1999·Molecular and Cellular Endocrinology·V M DarrasT J Visser
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·N A HukriedeM Ekker
Dec 22, 1999·Biochemical and Biophysical Research Communications·T InuiO Hayaishi
Feb 10, 2000·Molecular Biology and Evolution·M D GanforninaD Sánchez
Feb 11, 2000·Vitamins and Hormones·Y Urade, O Hayaishi
Mar 17, 2000·Science·T MatsuokaS Narumiya
Jul 19, 2000·Journal of Neurochemistry·L F García-FernándezA Muñoz
Nov 4, 2000·Biochimica Et Biophysica Acta·B AkerstromJ P Salier
Nov 4, 2000·Biochimica Et Biophysica Acta·J P Salier
Nov 4, 2000·Biochimica Et Biophysica Acta·D R Flower
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yasushi FujitaniYoshihiro Urade
Jan 23, 2002·Biochemistry·Eric A Nalefski, Joseph J Falke
Feb 15, 2002·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Osamu Hayaishi, Yoshihiro Urade
May 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·Tilo GrosserGarret A FitzGerald
Nov 21, 2002·The Journal of Biological Chemistry·Takashi InuiYoshihiro Urade
Jun 28, 2003·Molecular Endocrinology·Michio OtsukiJan-Ake Gustafsson
Sep 18, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Bhaja K PadhiMarie-Andrée Akimenko
Dec 4, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Barbara PiniGarret A FitzGerald
Feb 19, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Megumi MiyagiToshiyuki Sasaguri

❮ Previous
Next ❯

Citations

Sep 5, 2012·Environmental Science and Pollution Research International·Estérine EvrardJean Laroche
Sep 29, 2011·Chemical Reviews·William L SmithPer-Johan Jakobsson
Apr 21, 2010·Journal of Biochemistry·Kazuhisa TakedaShigeki Shibahara
Aug 27, 2013·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Gunti SreenivasuluBalasubramanian Senthilkumaran
Apr 7, 2010·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Anne JørgensenHenrik Leffers
Oct 16, 2015·Molecular Immunology·Victoria Gómez-Abellán, María P Sepulcre
Oct 20, 2006·Molecular Immunology·Santiago Fernandez GonzalezAndrew Cossins
Jun 2, 2015·Developmental and Comparative Immunology·Victoria Gómez-AbellánMaría P Sepulcre
Feb 25, 2010·Allergology International : Official Journal of the Japanese Society of Allergology·Makiko SuzukiMitsuru Seishima
Dec 6, 2014·Biochemical and Biophysical Research Communications·Whasun LimGwonhwa Song
Jun 13, 2014·Biology of Reproduction·Ajay Pradhan, Per-Erik Olsson
Jul 30, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yangyan ZhouZhi-Jie Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation
B MoniotF Poulat
Proceedings of the National Academy of Sciences of the United States of America
N EguchiO Hayaishi
© 2022 Meta ULC. All rights reserved