Zebrafish exposure to environmentally relevant concentration of depleted uranium impairs progeny development at the molecular and histological levels

PloS One
Olivier ArmantChristelle Adam-Guillermin

Abstract

Uranium is an actinide naturally found in the environment. Anthropogenic activities lead to the release of increasing amounts of uranium and depleted uranium (DU) in the environment, posing potential risks to aquatic organisms due to radiological and chemical toxicity of this radionucleide. Although environmental contaminations with high levels of uranium have already been observed, chronic exposures of non-human species to levels close to the environmental quality standards remain scarcely characterized. The present study focused on the identification of the molecular pathways impacted by a chronic exposure of zebrafish to 20 μg/L of DU during 10 days. The transcriptomic effects were evaluated by the use of the mRNAseq analysis in three organs of adult zebrafish, the brain the testis and the ovaries, and two developmental stages of the adult fish progeny, two-cells embryo and four-days larvae. The results highlight generic effects on the cell adhesion process, but also specific transcriptomic responses depending on the organ or the developmental stage investigated. The analysis of the transgenerational effects of DU-exposure on the four-day zebrafish larvae demonstrate an induction of genes involved in oxidative response (cat,...Continue Reading

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Citations

Oct 18, 2019·Biological Trace Element Research·Shuang WangYuhui Hao
Jul 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Thiloma D LiyanageIlson Whang
May 18, 2018·Environmental Health and Preventive Medicine·Yong-Chao YueWei He
Aug 7, 2020·Journal of Environmental Radioactivity·Yonghong RanYuhui Hao
Jun 4, 2019·The Science of the Total Environment·Quentin PetitjeanLisa Jacquin
Jul 31, 2018·Chemical Research in Toxicology·Hardik MakkarMrutyunjay Suar

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Methods Mentioned

BETA
transmission electronic microscopy
Chips
PCR
chromosomal aberrations
nuclear translocation

Software Mentioned

MA
R
LAS EZ
DESeq2
R package TopGO
Ensembl
STAR
ARRIVE
hclust
TopGO

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