Zebrafish fgfr1 is a member of the fgf8 synexpression group and is required for fgf8 signalling at the midbrain-hindbrain boundary

Development Genes and Evolution
Steffen ScholppMichael Brand

Abstract

FGFR1 is an important signalling molecule during embryogenesis and in adulthood. FGFR1 mutations in human may lead to developmental defects and pathological conditions, including cancer and Alzheimer's disease. Here, we describe cloning and expression analysis of the zebrafish fibroblast growth factor receptor 1 ( fgfr1). Initially, fgfr1 is expressed in the adaxial mesoderm with transcripts distinctly localised to the anterior portion of each half-somite. Hereupon, fgfr1 is also strongly expressed in the otic vesicles, branchial arches and the brain, especially at the midbrain-hindbrain boundary (MHB). The expression patterns of fgfr1 and fgf8 are strikingly similar and knock-down of fgfr1 phenocopies many aspects observed in the fgf8 mutant acerebellar, suggesting that Fgf8 exerts its function mainly by binding to FgfR1.

Citations

Nov 24, 2004·Development Genes and Evolution·Volker Hartenstein, Diethard Tautz
Nov 29, 2007·Zebrafish·Nobuyuki Itoh, Morichika Konishi
Jun 8, 2007·BMC Developmental Biology·Gabriela A MolinaMichael Tsang
Nov 20, 2009·BMC Research Notes·Svanhild NornesMichael Lardelli
Jan 28, 2014·PloS One·Charanya RengarajanSteffen Scholpp
Nov 2, 2013·Differentiation; Research in Biological Diversity·Arnaud LarbuissonMarc Muller
May 15, 2013·Current Opinion in Genetics & Development·Christian Bökel, Michael Brand
Mar 1, 2007·Journal of Neurochemistry·Juha Partanen
Jul 31, 2008·The Journal of Comparative Neurology·Stefanie ToppLaure Bally-Cuif
Jul 19, 2011·The EMBO Journal·Avinash PersaudDaniela Rotin
Oct 21, 2010·Genesis : the Journal of Genetics and Development·Satoshi OtaKyo Yamasu
Nov 16, 2004·Trends in Neurosciences·Florian Raible, Michael Brand
Jun 17, 2006·Molecular and Cellular Endocrinology·K E WhitlockS Twomey
Jul 16, 2013·Gene Expression Patterns : GEP·Patricia RohsSarah McFarlane
Jul 19, 2011·Mechanisms of Development·Steven J Deimling, Thomas A Drysdale
Feb 17, 2009·BMC Developmental Biology·Haruki Ochi, Monte Westerfield
Oct 23, 2004·Current Biology : CB·Steffen Scholpp, Michael Brand
Sep 7, 2011·BMC Developmental Biology·Sabine FischerJohan Ledin
Dec 20, 2007·Developmental Biology·Yoshiaki NakayamaNobuyuki Itoh
Mar 27, 2007·Developmental Biology·Claire A CanningC Michael Jones
Jan 24, 2007·BMC Developmental Biology·Stefan HansMonte Westerfield
Aug 7, 2010·BMC Developmental Biology·Sarah Tulin, Angelike Stathopoulos
Feb 21, 2008·BMC Developmental Biology·Marco J KoudijsFredericus Jm van Eeden

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.