Zebrafish Leucocyte tyrosine kinase controls iridophore establishment, proliferation and survival

Pigment Cell & Melanoma Research
Andrey FadeevChristiane Nüsslein-Volhard

Abstract

The zebrafish striped pattern results from the interplay among three pigment cell types; black melanophores, yellow xanthophores and silvery iridophores, making it a valuable model to study pattern formation in vivo. It has been suggested that iridophore proliferation, dispersal and cell shape transitions play an important role during stripe formation; however, the underlying molecular mechanisms remain poorly understood. Using gain- and loss-of-function alleles of leucocyte tyrosine kinase (ltk) and a pharmacological inhibitor approach, we show that Ltk specifically regulates iridophore establishment, proliferation and survival. Mutants in shady/ltk lack iridophores and display an abnormal body stripe pattern. Moonstone mutants, ltk(mne) , display ectopic iridophores, suggesting hyperactivity of the mutant Ltk. The dominant ltk(mne) allele carries a missense mutation in a conserved position of the kinase domain that highly correlates with neuroblastomas in mammals. Chimeric analysis suggests a novel physiological role of Ltk in the regulation of iridophore proliferation by homotypic competition.

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Citations

Aug 31, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B Hallberg, R H Palmer
Jan 11, 2018·Proceedings of the National Academy of Sciences of the United States of America·Andrey FadeevRuth H Palmer
Oct 29, 2017·Proceedings of the National Academy of Sciences of the United States of America·Elizabeth S MoStefania Nicoli
Feb 26, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Ganesh UmapathyRuth H Palmer
Apr 28, 2016·Nature Communications·Brigitte WalderichChristiane Nüsslein-Volhard
Feb 27, 2020·Proceedings of the National Academy of Sciences of the United States of America·Melissa R McGuirlBjörn Sandstede
Aug 15, 2018·Nature Communications·Alexandria Volkening, Björn Sandstede
Sep 12, 2019·Annual Review of Genetics·Larissa B Patterson, David M Parichy
Oct 13, 2020·EvoDevo·Natacha RouxVincent Laudet
Mar 2, 2019·Trends in Genetics : TIG·Pauline SalisBruno Frédérich
Jun 21, 2021·EvoDevo·Marleen KlannVincent Laudet
Jun 25, 2021·PLoS Genetics·Longhua GuoLeonid Kruglyak
May 15, 2021·Genome Biology and Evolution·Pietro Longo Hollanda de MelloRichard E Glor

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