Zebrafish models: do we have valid paradigms for depression?

Journal of Pharmacological and Toxicological Methods
Murilo S de AbreuA V Kalueff

Abstract

Depression is a wide-spread, debilitating psychiatric disorder. Mainly rodent-based, experimental animal models of depression are extensively used to probe the pathogenesis of this disorder. Here, we emphasize the need for innovative approaches to studying depression, and call for a wider use of novel model organisms, such as the zebrafish (Danio rerio), in this field. Highly homologous to humans and rodents, zebrafish are rapidly becoming a valuable tool in translational neuroscience research, but have only recently been utilized in depression research. Multiple conceptual and methodological problems, however, arise in relation to separating putative zebrafish depression-like states from motor and social deficits or anxiety. Here, we examine recent findings and the existing challenges in this field, to encourage further research and the use of zebrafish as novel organisms in cross-species depression modeling.

Citations

Feb 23, 2019·Expert Opinion on Drug Discovery·Konstantin A DeminAllan V Kalueff
Mar 22, 2019·Drug and Chemical Toxicology·Qiang YeLi Guo
May 16, 2019·The European Journal of Neuroscience·Rafael GenarioAllan V Kalueff
Feb 11, 2020·Stress : the International Journal on the Biology of Stress·Konstantin A DeminAllan V Kalueff
Apr 15, 2020·Pharmacology, Biochemistry, and Behavior·Murilo S de AbreuAllan V Kalueff

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