Zebrafish models for cancer

doi:10.1146/annurev-pathol-011110-130330

PMID: 21261518DOI: 10.1146/annurev-pathol-011110-130330Jan 26, 2011Paper

Zebrafish models for cancer

Annual Review of Pathology

Shu Liu, Steven D Leach

Abstract

First established as a valuable vertebrate model system for studying development, zebrafish have emerged as an attractive animal system for modeling human cancers. Major technical advances have been essential for the generation of zebrafish cancer models relevant to human diseases. These models develop tumors in various organ sites that bear striking resemblance to human malignances, both histologically and genetically. Thus, the focus of cancer research in zebrafish has transcended the need to validate zebrafish as a viable model organism to study cancer biology. With the significant advantages of in vivo imaging, the power of forward genetics, well-established high efficiency for transgenesis, and ease of transplantation, further exploration of the zebrafish cancer models not only will generate unique insights into underlying mechanisms of cancer but will also provide platforms useful for drug discovery.

References

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Mar 29, 1992·Nature·L A DonehowerA Bradley

Identification and characterization of the familial adenomatous polyposis coli gene.

Aug 9, 1991·Cell·J GrodenM Robertson

Identification of FAP locus genes from chromosome 5q21.

Aug 9, 1991·Science·K W KinzlerD McKechnie

High-frequency germ-line transmission of plasmid DNA sequences injected into fertilized zebrafish eggs

Sep 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P CulpN Hopkins

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms.

Dec 10, 1990·Science·D MalkinM A Tainsky

An amino-terminal fragment of GAL4 binds DNA as a dimer

Oct 5, 1989·Journal of Molecular Biology·M CareyM Ptashne

Clonal origins of cells in the pigmented retina of the zebrafish eye

Jan 1, 1989·Developmental Biology·G StreisingerD J Grunwald

GAL4-VP16 is an unusually potent transcriptional activator

Oct 6, 1988·Nature·I SadowskiM Ptashne

Transcription in yeast activated by a putative amphipathic alpha helix linked to a DNA binding unit

Dec 17, 1987·Nature·E Giniger, M Ptashne

Specific DNA binding of GAL4, a positive regulatory protein of yeast

Apr 1, 1985·Cell·E GinigerM Ptashne

A GAL10-CYC1 hybrid yeast promoter identifies the GAL4 regulatory region as an upstream site

Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·L GuarenteP Gifford

Production of clones of homozygous diploid zebra fish (Brachydanio rerio)

May 28, 1981·Nature·G StreisingerF Singer

K-ras mutation and pancreatic adenocarcinoma

Aug 1, 1995·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·C Caldas, S E Kern

Tumor spectrum analysis in p53-mutant mice

Jan 1, 1994·Current Biology : CB·T JacksR A Weinberg

Insulin-promoter-factor 1 is required for pancreas development in mice

Oct 13, 1994·Nature·J JonssonH Edlund

Efficient recovery of ENU-induced mutations from the zebrafish germline.

Apr 1, 1994·Genetics·L Solnica-KrezelW Driever

Zebrafish: genetic tools for studying vertebrate development

May 1, 1994·Trends in Genetics : TIG·W DrieverL Solnica-Krezel

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

Dec 3, 1993·Cell·R C LeeV Ambros

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

Dec 3, 1993·Cell·B WightmanG Ruvkun

Highly efficient germ-line transmission of proviral insertions in zebrafish

Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·N GaianoN Hopkins

Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis

Aug 1, 1996·Genes & Development·L GirardP Jolicoeur

Transposition of the nematode Caenorhabditis elegans Tc3 element in the zebrafish Danio rerio

Mar 21, 1998·Current Biology : CB·E RazW Driever

Transposition of the mariner element from Drosophila mauritiana in zebrafish

Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·J M FadoolJ E Dowling

The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas

Dec 16, 1998·Genes & Development·A KrappP K Wellauer

Excision of the tol2 transposable element of the medaka fish, Oryzias latipes, in zebrafish, Danio rerio

Feb 5, 1999·Gene·K KawakamiA Shima

The role of p53 in tumour suppression: lessons from mouse models

Mar 5, 1999·Cellular and Molecular Life Sciences : CMLS·L D Attardi, T Jacks

Use of the Gal4-UAS technique for targeted gene expression in the zebrafish

Mar 12, 1999·Mechanisms of Development·N Scheer, J A Campos-Ortega

Transgene expression in zebrafish: A comparison of retroviral-vector and DNA-injection approaches

Aug 24, 1999·Developmental Biology·E LinneyL DiNapoli

Transgenic models of lymphoid neoplasia and development of a pan-hematopoietic vector

Sep 28, 1999·Oncogene·J M AdamsS Cory

Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases

Oct 28, 1999·Nucleic Acids Research·A K IndraD Metzger

Identification of the Tol2 transposase of the medaka fish Oryzias latipes that catalyzes excision of a nonautonomous Tol2 element in zebrafish Danio rerio

Nov 24, 1999·Gene·K Kawakami, A Shima

Effective targeted gene 'knockdown' in zebrafish

Oct 4, 2000·Nature Genetics·A Nasevicius, S C Ekker

Identification of a functional transposase of the Tol2 element, an Ac-like element from the Japanese medaka fish, and its transposition in the zebrafish germ lineage

Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·K KawakamiN Kawakami

Morphants: a new systematic vertebrate functional genomics approach

Dec 19, 2000·Yeast·S C Ekker

Tracing transgene expression in living zebrafish embryos

May 5, 2001·Developmental Biology·R W Köster, S E Fraser

The expression of ETV6/CBFA2 (TEL/AML1) is not sufficient for the transformation of hematopoietic cell lines in vitro or the induction of hematologic disease in vivo

Oct 25, 2001·Cancer Genetics and Cytogenetics·P AndreassonD G Gilliland

The IARC TP53 database: new online mutation analysis and recommendations to users

May 15, 2002·Human Mutation·Magali OlivierPierre Hainaut

RNA silencing: the genome's immune system

May 23, 2002·Science·Ronald H A Plasterk

Ancient pathways programmed by small RNAs

May 23, 2002·Science·Phillip D Zamore

Mutations of the BRAF gene in human cancer

Jun 18, 2002·Nature·Helen DaviesP Andrew Futreal

Zebrafish as a cancer model system

Jun 28, 2002·Cancer Cell·James F AmatrudaLeonard I Zon

Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia

Jun 28, 2002·Cancer Cell·Adolfo A FerrandoA Thomas Look

Target-selected inactivation of the zebrafish rag1 gene

Jul 6, 2002·Science·Erno WienholdsRonald H A Plasterk

Headwaters of the zebrafish -- emergence of a new model vertebrate

Sep 5, 2002·Nature Reviews. Genetics·David Jonah Grunwald, Judith S Eisen

I-SceI meganuclease mediates highly efficient transgenesis in fish

Sep 28, 2002·Mechanisms of Development·Violette ThermesJean-Stéphane Joly

Zebrafish as a model organism for the identification and characterization of drugs and genes affecting p53 signaling

Dec 13, 2002·Current Biology : CB·Ulrike LangheinrichGabi Vacun

Myc-induced T cell leukemia in transgenic zebrafish

Feb 8, 2003·Science·David M LangenauA Thomas Look

The UMD-p53 database: new mutations and analysis tools

Mar 6, 2003·Human Mutation·Christophe Béroud, Thierry Soussi

Perturbation of Ikaros isoform selection by MLV integration is a cooperative event in Notch(IC)-induced T cell leukemogenesis

Jul 5, 2003·Cancer Cell·Levi J Beverly, Anthony J Capobianco

❮ Previous

Next ❯

Citations

Generation and application of signaling pathway reporter lines in zebrafish.

May 16, 2013·Molecular Genetics and Genomics : MGG·Enrico MoroFrancesco Argenton

Zebrafish as a model for systems biology

Feb 27, 2014·Biotechnology & Genetic Engineering Reviews·Mian Yahya MushtaqHye Kyong Kim

EuFishBioMed (COST Action BM0804): a European network to promote the use of small fishes in biomedical research.

Apr 28, 2012·Zebrafish·Uwe SträhleGudrun Knedlitschek

Neuroprotective effect of zinc chelator DEDTC in a zebrafish (Danio rerio) Model of Hypoxic Brain Injury

Mar 7, 2013·Zebrafish·Xinge Yu, Yang V Li

A retrospective study of the prevalence and classification of intestinal neoplasia in zebrafish (Danio rerio)

Apr 3, 2013·Zebrafish·Colleen E PaquetteTracy S Peterson

Getting the inside tract: new frontiers in zebrafish digestive system biology

Jun 7, 2013·Zebrafish·Kirsten C SadlerSteven A Farber

Documented and potential research impacts of subclinical diseases in zebrafish

Feb 6, 2013·ILAR Journal·Michael L KentJeffrey C Wolf

Repertoire of protein kinases encoded in the genome of zebrafish shows remarkably large population of PIM kinases

Jan 29, 2014·Journal of Bioinformatics and Computational Biology·R RakshambikaiRupali A Gadkari

Hooked! Modeling human disease in zebrafish.

Jul 4, 2012·The Journal of Clinical Investigation·Cristina Santoriello, Leonard I Zon

Hepatic stellate cells in liver development, regeneration, and cancer

May 3, 2013·The Journal of Clinical Investigation·Chunyue YinDidier Y R Stainier

Orthotopic transplantation of retinoblastoma cells into vitreous cavity of zebrafish for screening of anticancer drugs

Jul 10, 2013·Molecular Cancer·Dong Hyun JoJeong Hun Kim

An inducible kras(V12) transgenic zebrafish model for liver tumorigenesis and chemical drug screening.

Sep 10, 2011·Disease Models & Mechanisms·Anh Tuan NguyenZhiyuan Gong

A transgenic zebrafish liver tumor model with inducible Myc expression reveals conserved Myc signatures with mammalian liver tumors.

Oct 6, 2012·Disease Models & Mechanisms·Zhen LiZhiyuan Gong

Transmembrane voltage potential is an essential cellular parameter for the detection and control of tumor development in a Xenopus model

Mar 9, 2013·Disease Models & Mechanisms·Brook T Chernet, Michael Levin

Mutations in LRRC50 predispose zebrafish and humans to seminomas

Apr 20, 2013·PLoS Genetics·Sander G BastenRachel H Giles

Cross-species array comparative genomic hybridization identifies novel oncogenic events in zebrafish and human embryonal rhabdomyosarcoma

Sep 7, 2013·PLoS Genetics·Eleanor Y ChenDavid M Langenau

Vasa-Like DEAD-Box RNA Helicases of Schistosoma mansoni.

Jun 22, 2012·PLoS Neglected Tropical Diseases·Danielle E SkinnerPaul J Brindley

Reversed scototaxis during withdrawal after daily-moderate, but not weekly-binge, administration of ethanol in zebrafish

May 16, 2013·PloS One·Adam HolcombeTrevor J Hamilton

Soybean meal induces intestinal inflammation in zebrafish larvae

Jul 31, 2013·PloS One·Manuel I HedreraCarmen G Feijóo

Xmrk, kras and myc transgenic zebrafish liver cancer models share molecular signatures with subsets of human hepatocellular carcinoma

Mar 19, 2014·PloS One·Weiling ZhengZhiyuan Gong

Pseudotyped murine leukemia virus for schistosome transgenesis: approaches, methods and perspectives

Jan 30, 2014·Transgenic Research·Victoria H MannGabriel Rinaldi

Tumor suppressors: enhancers or suppressors of regeneration?

May 30, 2013·Development·Jason H Pomerantz, Helen M Blau

Microfluidics: A new tool for modeling cancer-immune interactions

Feb 10, 2016·Trends in Cancer·Alexandra Boussommier-CallejaRoger D Kamm

Polyphosphazene vesicles for co-delivery of doxorubicin and chloroquine with enhanced anticancer efficacy by drug resistance reversal

Dec 15, 2015·International Journal of Pharmaceutics·Jing XuLiyan Qiu

The zebrafish as a tool in leukemia research

Jul 4, 2012·Leukemia Research·Kaisa J TeittinenOlli Lohi

Screening of anti-cancer agent using zebrafish: comparison with the MTT assay

May 9, 2012·Biochemical and Biophysical Research Communications·Yigen LiCheng Huang

Generation of transgenic zebrafish with liver-specific expression of EGFP-Lc3: a new in vivo model for investigation of liver autophagy

May 15, 2012·Biochemical and Biophysical Research Communications·Jianzhou CuiHan-Ming Shen

Zebrafish cancer and metastasis models for in vivo drug discovery

Sep 21, 2013·Drug Discovery Today. Technologies·Jennifer TatXiao-Yan Wen

Predominant Activation of JAK/STAT3 Pathway by Interleukin-6 Is Implicated in Hepatocarcinogenesis

Aug 25, 2015·Neoplasia : an International Journal for Oncology Research·In Hye JungSeung Woo Park

Immunohistochemical characterization of intestinal neoplasia in zebrafish Danio rerio indicates epithelial origin

Oct 28, 2015·Diseases of Aquatic Organisms·Colleen E PaquetteChristiane V Löhr

Development of zebrafish epidermis

Sep 21, 2011·Birth Defects Research. Part C, Embryo Today : Reviews·Wei-Jen Chang, Pung-Pung Hwang

Use of zebrafish embryos for small molecule screening related to cancer

Dec 4, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Javier Terriente, Cristina Pujades

Small molecule screening in zebrafish: swimming in potential drug therapies.

Jun 27, 2013·Wiley Interdisciplinary Reviews. Developmental Biology·Owen J TamplinLeonard I Zon

The zebrafish as a model for nociception studies

Apr 6, 2013·Journal of Cellular Physiology·Valentina MalafogliaGianfranco Bellipanni

Zebrafish xenografts as a tool for in vivo studies on human cancer

Aug 21, 2012·Annals of the New York Academy of Sciences·Martina KonantzClaudia Lengerke

Fishing the targets of myeloid malignancies in the era of next generation sequencing

Oct 8, 2015·Blood Reviews·Xiangguo ShiAnskar Y H Leung

Fish is Fish: the use of experimental model species to reveal causes of skeletal diversity in evolution and disease

Sep 16, 2014·Zeitschrift Für Angewandte Ichthyologie = Journal of Applied Ichthyology·M P HarrisP E Witten

Ewing sarcoma inhibition by disruption of EWSR1-FLI1 transcriptional activity and reactivation of p53

Jul 1, 2014·The Journal of Pathology·Wietske van der EntB Ewa Snaar-Jagalska

Set-up of an infrared fast behavioral assay using zebrafish (Danio rerio) larvae, and its application in compound biotoxicity screening

Feb 13, 2013·Journal of Applied Toxicology : JAT·Darío BicharaSergio H Simonetta

The novel protective role of P27 in MLN4924-treated gastric cancer cells

Aug 28, 2015·Cell Death & Disease·Q ZhangJ Liu

Zebrafish models of cancer: progress and future challenges

Mar 25, 2014·Current Opinion in Genetics & Development·Jennifer YenDerek L Stemple

Complex regulation of autophagy in cancer - integrated approaches to discover the networks that hold a double-edged sword

Jul 3, 2013·Seminars in Cancer Biology·János KubischTamás Korcsmáros

The zebrafish as a model for complex tissue regeneration

Aug 10, 2013·Trends in Genetics : TIG·Matthew GemberlingKenneth D Poss

A triazine compound S06 inhibits proinvasive crosstalk between carcinoma cells and stromal fibroblasts via binding to heat shock protein 90

Dec 27, 2011·Chemistry & Biology·Da-Woon JungJin Kim

Mechanism of inhibition of CYP1A1 and glutathione S-transferase activities in fish liver by quercetin, resveratrol, naringenin, hesperidin, and rutin

Nov 6, 2014·Nutrition and Cancer·Emel ArinçAzra Bozcaarmutlu

CREB engages C/EBPδ to initiate leukemogenesis

Apr 28, 2016·Leukemia·C TregnagoM Pigazzi

Development of a vestibular schwannoma xenograft zebrafish model for in vivo antitumor drug screening

Jun 1, 2016·The Laryngoscope·Hyun-Jin LeeIn Seok Moon

Ultrastructural Mapping of the Zebrafish Gastrointestinal System as a Basis for Experimental Drug Studies

Jun 25, 2016·BioMed Research International·Delfine ChengFilip Braet

Evaluating human cancer cell metastasis in zebrafish

Oct 5, 2013·BMC Cancer·Yong TengJohn K Cowell

Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish

Jul 3, 2015·PLoS Genetics·Kimberley J EvasonDidier Y R Stainier

❮ Previous

Next ❯

Methods Mentioned

transgenic

gene knockdown

antisense oligonucleotides

xenograft

xenografts

ubiquitination

MDS

Software Mentioned

TILLING

OPEN

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.