Zebrafish models for functional and toxicological screening of nanoscale drug delivery systems: promoting preclinical applications

Bioscience Reports
Keon Yong LeeKwan Hyi Lee

Abstract

Preclinical screening with animal models is an important initial step in clinical translation of new drug delivery systems. However, establishing efficacy, biodistribution, and biotoxicity of complex, multicomponent systems in small animal models can be expensive and time-consuming. Zebrafish models represent an alternative for preclinical studies for nanoscale drug delivery systems. These models allow easy optical imaging, large sample size, and organ-specific studies, and hence an increasing number of preclinical studies are employing zebrafish models. In this review, we introduce various models and discuss recent studies of nanoscale drug delivery systems in zebrafish models. Also in the end, we proposed a guideline for the preclinical trials to accelerate the progress in this field.

References

Sep 25, 1999·Behavior Research Methods, Instruments, & Computers : a Journal of the Psychonomic Society, Inc·J BilottaH R Hardesty
May 29, 2000·Current Opinion in Genetics & Development·K Dooley, L I Zon
Sep 14, 2000·Genome Research·W B BarbazukS L Johnson
May 30, 2001·Molecular and Cellular Endocrinology·H HuangS Lin
Dec 18, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Josephine P Briggs
Jun 28, 2002·Cancer Cell·James F AmatrudaLeonard I Zon
Aug 9, 2002·Developmental Biology·Nathan D Lawson, Brant M Weinstein
Aug 27, 2002·Current Biology : CB·Hinrich HabeckUNKNOWN Tübingen 2000 screen consortium
Jun 13, 2003·Journal of Medicinal Chemistry·Chester A MathisWilliam E Klunk
Jul 2, 2003·Nature Reviews. Cancer·Howard M Stern, Leonard I Zon
Sep 2, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Chiu-Ju HuangHuai-Jen Tsai
Apr 20, 2004·Assay and Drug Development Technologies·Chuenlei ParngPatricia McGrath
Sep 24, 2004·International Journal of Experimental Pathology·Carolyn A StatonClaire E Lewis
Sep 24, 2004·Trends in Microbiology·Astrid M van der SarWilbert Bitter
Feb 3, 2005·Nature Reviews. Drug Discovery·Leonard I Zon, Randall T Peterson
Aug 25, 2005·BioTechniques·Stephane BerghmansJohn P Kanki
Sep 2, 2005·Nature·UNKNOWN Chimpanzee Sequencing and Analysis Consortium
Oct 28, 2005·Development·Suk-Won JinDidier Y R Stainier
Nov 29, 2005·Trends in Biotechnology·Peter AleströmRasoul Nourizadeh-Lillabadi
Jan 13, 2006·Nature Chemical Biology·C Geoffrey BurnsMark C Fishman
Feb 9, 2006·Journal of the American Chemical Society·Xiaohua HuangMostafa A El-Sayed
Feb 13, 2007·Nanomedicine : Nanotechnology, Biology, and Medicine·Ruchika Nijhara, Krishna Balakrishnan
Apr 6, 2007·Cancer Research·Stefania NicoliMarco Presta
Apr 19, 2007·Nature Reviews. Genetics·Graham J Lieschke, Peter D Currie
May 15, 2007·Clinical Pharmacology and Therapeutics·G KariA P Dicker
Oct 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Konstantin StoletovRichard Klemke
Nov 17, 2007·Nature Protocols·Stefania Nicoli, Marco Presta
Mar 29, 2008·Cell Stem Cell·Richard Mark WhiteLeonard I Zon
Apr 1, 2008·Oncogene·K Stoletov, R Klemke
May 13, 2008·Drug Discovery Today·Patricia McGrath, Chun-Qi Li
May 30, 2008·Advanced Drug Delivery Reviews·Jason R McCarthy, Ralph Weissleder
Aug 6, 2008·Pediatric Research·Matthew B Veldman, Shuo Lin
Sep 18, 2008·BMC Developmental Biology·Svetlana KorzhZhiyuan Gong
Oct 29, 2008·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Helmut Segner
Dec 17, 2008·International Journal of Andrology·Serap GurWayne J G Hellstrom
Apr 1, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ramesh C NagarwalJ K Pandit
Apr 25, 2009·Advanced Drug Delivery Reviews·Valerie E Fako, Darin Y Furgeson

❮ Previous
Next ❯

Citations

Dec 31, 2017·Drug Delivery and Translational Research·Maria Natalia CalienniJorge Montanari
Jun 28, 2018·Nanomedicine·Cristian R LilloJorge Montanari
Oct 16, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Alexandra UlinLarissa M Williams
Oct 23, 2020·Zebrafish·Nicholas Silvestre de Souza TrigueiroThiago Lopes Rocha
Apr 3, 2021·Advanced Drug Delivery Reviews·Paz Boix-MontesinosMaría J Vicent
Jul 3, 2021·Pharmaceuticals·Hissa F Al-ThaniHuseyin C Yalcin
Aug 8, 2021·Nanomaterials·Alba Pensado-LópezFernando Torres Andón
Feb 23, 2020·Biomacromolecules·Victorio Saez TalensRoxanne E Kieltyka
Nov 7, 2019·The Journal of Organic Chemistry·Carlos E Puerto Galvis, Vladimir V Kouznetsov

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
xenograft
X-ray

Software Mentioned

Ensembl browser

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.