Zebrafish p53 protein enhances the translation of its own mRNA in response to UV irradiation and CPT treatment

FEBS Letters
Xiangzhong ZhaoXiukun Lin

Abstract

p53 protein is an important regulatory factor involved in cell growth and development. In our previous study, we demonstrated that recombined zebrafish p53 protein could specifically bind to its own mRNA in vitro. To determine if a similar interaction exists in zebrafish and if this interaction affects zebrafish development, in the present study, we investigated the interaction of p53 protein and its mRNA in zebrafish embryos. Our results revealed that expressed zebrafish p53 protein could bind with its own mRNA in zebrafish embryos. Furthermore, the endogenous activated or ectopically expressed p53 protein could enhance the relative activity of Renilla luciferase fused with p53 3'UTR in response to UV irradiation and CPT treatment, and retarded development of zebrafish embryos was observed.

References

Sep 15, 1995·The EMBO Journal·J MosnerW Deppert
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·E ChuC J Allegra
Jul 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C B KimmelT F Schilling
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·J JuE Chu
Apr 26, 2001·Apoptosis : an International Journal on Programmed Cell Death·D E Fisher
May 29, 2001·American Journal of Medical Genetics·J L Lohr, H J Yost
Jun 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Krystyna Mazan-MamczarzMyriam Gorospe
Mar 10, 2004·Ophthalmic Research·Anne S Glass, Ralf Dahm
Apr 8, 2006·Cell Death and Differentiation·M F Lavin, N Gueven
Jun 6, 2006·Journal of Biochemistry·Changqing DuXiukun Lin
Sep 6, 2008·Birth Defects Research. Part C, Embryo Today : Reviews·Nadia DanilovaShuo Lin
Jan 1, 2007·Recent Patents on DNA & Gene Sequences·David Reisman, Kristy Boggs
Mar 12, 2009·Current Drug Metabolism·Chiranjib ChakrabortyGovindasamy Agoramoorthy
Nov 10, 2009·Seminars in Cancer Biology·Nerea Allende-Vega, Mark K Saville

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis