Zebrafish R-cadherin (Cdh4) controls visual system development and differentiation

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Sherry G BabbJ A Marrs


In zebrafish, R-cadherin (cadherin-4 or Cdh4) is expressed in the retina and in retinorecipient brain regions, suggesting that Cdh4 functions during visual system development. Cdh4 function was examined during retinogenesis and retinal axon outgrowth using antisense morpholino oligonucleotides and mutant Cdh4 construct expression. In knockdowns, Cdh4 was reduced or absent, eyes were small, and retinae lacked discrete laminae. Increased cell death produced the small eye phenotype. Zn5-, Pax6-, and zpr-1-positive cells were reduced or absent in knockdown retinas but, when present, were in the correct laminae. Cdh4 knockdowns had sparse or absent retinal ganglion cell axons. When present, axons projected contralaterally but lacked fine branching and failed to reach the tectum or arborize the entire tectum. Mutant Cdh4 construct expression during retinal ganglion cell differentiation reduced or ablated neurite formation. Cdh4 is necessary for neural retina survival and differentiation, and required for normal retinotectal projection formation and tectal arborization.


May 21, 2011·Molecular Biology Reports·Xinbing SuiXiaotong Hu
May 25, 2006·BMC Developmental Biology·Brian BagattoQ Liu
Nov 13, 2007·BMC Developmental Biology·Allisan Aquilina-BeckJennifer O Liang
Mar 30, 2007·Arthritis Research & Therapy·Farida DjouadChristian Jorgensen
Dec 4, 2013·Proceedings of the National Academy of Sciences of the United States of America·Mark LommelSabine Strahl
Jul 31, 2012·General and Comparative Endocrinology·Q LiuRichard Londraville
Mar 4, 2010·Molecular and Cellular Neurosciences·Samantha A Oblander, Susann M Brady-Kalnay
Apr 1, 2008·Progress in Retinal and Eye Research·Lucia Galli-RestaElena Novelli
Sep 14, 2007·The Journal of Comparative Neurology·Lauren L DanieleNancy J Philp
May 18, 2012·The Journal of Comparative Neurology·Nicole HertelLoreta Medina
Jan 17, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sherry G ClendenonJ A Marrs
Aug 29, 2012·Developmental Neurobiology·Yun ChenQ Liu
Sep 30, 2010·The Journal of Comparative Neurology·Rajesh RamachandranDaniel Goldman
Jun 18, 2010·Developmental Neurobiology·Elisabeth Rungger-BrändleDuri Rungger
Apr 8, 2015·Journal of Neuroendocrinology·G M Coughlin, D M Kurrasch
Oct 13, 2006·Mechanisms of Development·Gui RuanAlmut Koehler
Sep 2, 2014·Gene Expression Patterns : GEP·John S Nuhn, Peter G Fuerst
Nov 22, 2014·Journal of Biochemistry·Yusuke IzutaS Suzuki
May 29, 2008·Developmental Neurobiology·Q LiuDavid G Fatkins
Apr 17, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Anne E CatalanoXiangyun Wei
Apr 27, 2012·Physiological Reviews·Shinji Hirano, Masatoshi Takeichi
Apr 10, 2019·Ecology and Evolution·Christopher M HollenbeckJohn R Gold
Aug 21, 2019·International Journal of Molecular Sciences·Davide CeresaIrene Appolloni
Feb 7, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Amy L WilsonQ Liu


Sep 1, 1990·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L K Barthel, Pamela A Raymond
Oct 1, 1990·The Journal of Cell Biology·M Ozawa, Rolf Kemler
Oct 1, 1994·Developmental Dynamics : an Official Publication of the American Association of Anatomists·S BitzurB Geiger
Aug 22, 1994·The Journal of Comparative Neurology·J D Burrill, S S Easter
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·M S Steinberg, M Takeichi
Jan 19, 1999·Methods in Cell Biology·T M Hyatt, S C Ekker
Jan 19, 1999·Methods in Cell Biology·M S CooperC A Henry
Apr 2, 1999·The Journal of Comparative Neurology·D Fashena, M Westerfield
Jul 22, 1999·The Journal of Comparative Neurology·Q LiuJ A Marrs
Feb 9, 2000·The Journal of Cell Biology·W S ShanL Shapiro
Feb 7, 2001·Developmental Biology·D L StenkampPamela A Raymond
Apr 25, 2000·Progress in Neurobiology·C Redies
Sep 23, 2000·Science·Carl J Neumann, C Nuesslein-Volhard
Oct 4, 2000·Nature Genetics·A Nasevicius, S C Ekker
Mar 20, 2001·Nature Reviews. Molecular Cell Biology·Ulrich TepassM Peifer
Nov 1, 2001·Nature Neuroscience·T W Yu, C I Bargmann
Nov 24, 2001·Brain Research. Developmental Brain Research·Q LiuPamela A Raymond
Dec 18, 2001·American Journal of Physiology. Cell Physiology·Jeffrey L ClendenonKenneth W Dunn
Dec 26, 2001·Nature Genetics·Joshua T GamseJennifer O Liang
Jan 11, 2002·Developmental Biology·L K Cole, L S Ross
Feb 13, 2002·Molecular and Cellular Biology·Ulf DahlHenrik Semb
Aug 30, 2002·Current Opinion in Genetics & Development·Ulrich TepassRudolf Winklbauer
Sep 7, 2002·Science·Mary E Hatten
Oct 10, 2002·Neuron·Thomas R Clandinin, S Lawrence Zipursky
Mar 11, 2003·Annual Review of Neuroscience·Oscar Marín, John L R Rubenstein
Mar 24, 2004·Seminars in Cell & Developmental Biology·Zac Pujic, Jarema Malicki
Apr 15, 2004·Developmental Biology·Yu-chi Shen, Pamela A Raymond

Related Concepts

Cdh4 protein, zebrafish
Apoptosis, Intrinsic Pathway
Entire Retina
CDH4 gene
Retinal Diseases
Lamiinae (invertebrate)
Neural Retina
Cell Differentiation Process

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.