Abstract
In sexually reproducing organisms, primordial germ cells (PGCs) give rise to the cells of the germ line, the gametes. In many animals, PGCs are set apart from somatic cells early during embryogenesis. Work in Drosophila, C. elegans, Xenopus, and zebrafish has shown that maternally provided localized cytoplasmic determinants specify the germ line in these organisms (Raz, E., 2003. Primordial germ-cell development: the zebrafish perspective. Nat. Rev., Genet. 4, 690--700; Santos, A.C., Lehmann, R., 2004. Germ cell specification and migration in Drosophila and beyond. Curr. Biol. 14, R578-R589). The Drosophila RNA-binding protein, Staufen is required for germ cell formation, and mutations in stau result in a maternal effect grandchild-less phenotype (Schupbach,T., Weischaus, E., 1989. Female sterile mutations on the second chromosome of Drosophila melanogaster:1. Maternal effect mutations. Genetics 121, 101-17). Here we describe the functions of two zebrafish Staufen-related proteins, Stau1 and Stau2. When Stau1 or Stau2 functions are compromised in embryos by injecting antisense morpholino modified oligonucleotides or dominant-negative Stau peptides, germ layer patterning is not affected. However, expression of the PGC marker vas...Continue Reading
References
Jul 30, 1992·Nature·A Ephrussi, R Lehmann
Jul 12, 1991·Cell·D St JohnstonC Nüsslein-Volhard
Feb 1, 1991·Analytical Biochemistry·K L Guan, J E Dixon
Jan 1, 1989·Genetics·T Schüpbach, E Wieschaus
Nov 25, 1988·Nucleic Acids Research·F Corpet
May 9, 1986·Cell·J B Lawrence, R H Singer
Sep 25, 1984·Nucleic Acids Research·P A Krieg, D A Melton
Oct 8, 1993·Cell·F S Neuman-Silberberg, T Schüpbach
Jun 15, 1994·Genes & Development·D L Turner, H Weintraub
Nov 11, 1994·Nucleic Acids Research·J D ThompsonT J Gibson
Jan 1, 1994·Genomics·S L JohnsonJ H Postlethwait
Jul 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C B KimmelT F Schilling
Aug 8, 1997·Cell·P LiW Chia
Mar 5, 1998·Nature·J BroadusC Q Doe
Jun 24, 1998·Genes & Development·C P ShenY N Jan
Jun 24, 1998·Genes & Development·A J SchuldtA H Brand
Feb 18, 1999·Molecular and Cellular Biology·R M MariónJ Ortín
Feb 18, 1999·Molecular and Cellular Biology·L WickhamL DesGroseillers
May 13, 1999·Bioinformatics·P GouetF Métoz
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·N A HukriedeM Ekker
Sep 3, 1999·Molecular Biology of the Cell·M KöhrmannM A Kiebler
Mar 16, 2000·The EMBO Journal·D R MicklemD St Johnston
May 10, 2000·Trends in Cell Biology·F Roegiers, Y N Jan
May 17, 2000·The Journal of Cell Biology·H KnautC Nüsslein-Volhard
Oct 25, 2000·Molecular Human Reproduction·P T SaundersM Bownes
Jan 9, 2001·Journal of Neurochemistry·M MonshausenS Kindler
Jan 11, 2001·Developmental Biology·T KondoM Yamashita
Jun 5, 2003·Development·Jing TianKaruna Sampath
Aug 23, 2003·Current Biology : CB·Gilbert WeidingerErez Raz
Sep 3, 2003·Nature Reviews. Genetics·Erez Raz
May 28, 2004·Development·Young J Yoon, Kimberly L Mowry
Jul 23, 2004·Current Biology : CB·Ana C Santos, Ruth Lehmann
Oct 22, 2004·RNA·Rachel AllisonNancy Standart
Feb 1, 2005·Cell·Yoon Ki KimLynne E Maquat
Apr 6, 2005·Nature Structural & Molecular Biology·Erika L Meyer, Elizabeth R Gavis
Apr 7, 2005·FEBS Letters·Hannah GautreyJohn Hesketh
Citations
Jun 2, 2007·BMC Developmental Biology·Bo Ram LeeJae Yong Han
Jan 14, 2011·Fish Physiology and Biochemistry·Ksenia J GrohMarc J-F Suter
Feb 3, 2009·Biochemical Genetics·Jian-Zhen LiFeng-Jiao Deng
Feb 5, 2016·Nucleic Acids Research·Xin ZhangLuc DesGroseillers
Sep 4, 2012·Molecular and Cellular Neurosciences·Diane M CockburnPhilippe P Monnier
Jul 3, 2010·Science China. Life Sciences·HongYan XuYunHan Hong
Jan 11, 2007·Seminars in Cancer Biology·Ujwal J PyatiMatthias Hammerschmidt
Dec 14, 2011·Genesis : the Journal of Genetics and Development·Cassandra K Bilogan, Marko E Horb
Feb 1, 2011·Proteomics·Xuefeng FangBiaoyang Lin
Oct 1, 2009·Molecular Reproduction and Development·Ben Ewen-CampenCassandra G M Extavour
Jan 23, 2014·Stem Cells·Srinivas RamasamySohail Ahmed
Jan 21, 2012·Journal of Ovarian Research·Michael F GallagherJohn J O'Leary
Jul 1, 2008·Biochimica Et Biophysica Acta·Hannah GautreyJohn Hesketh
Jul 12, 2014·Trends in Neurosciences·Jacki E Heraud-Farlow, Michael A Kiebler
Apr 25, 2009·Developmental Biology·Jordi SolanaRafael Romero
Feb 8, 2014·PloS One·Taiju SaitoEtsuro Yamaha
Sep 21, 2011·PloS One·Taiju SaitoEtsuro Yamaha
Jul 5, 2013·PloS One·Ten-Tsao Wong, Paul Collodi
Apr 16, 2015·ELife·Dana MeyenErez Raz
Jan 31, 2015·Marine Biotechnology·Melony J SellarsPhilip L Hertzler
Jun 21, 2008·Endocrinology·Xianpeng SangAntony W Wood
Dec 20, 2019·RNA·Silvia VisentinLaura Spagnolo
Jul 15, 2017·BMC Cell Biology·Rémy BeaujoisLuc DesGroseillers
Mar 6, 2021·BMC Molecular and Cell Biology·Lionel CondéLuc DesGroseillers
May 1, 2021·Animals : an Open Access Journal From MDPI·Xinghua LinChangxu Tian
May 22, 2021·Biological Reviews of the Cambridge Philosophical Society·Florence Bonnet-Magnaval, Luc DesGroseillers
Oct 12, 2021·Cellular and Molecular Life Sciences : CMLS·Shekoufeh Almasi, Bernard J Jasmin