Zein Increases the Cytoaffinity and Biodegradability of Scaffolds 3D-Printed with Zein and Poly(ε-caprolactone) Composite Ink

ACS Applied Materials & Interfaces
Linzhi JingDejian Huang

Abstract

Electrohydrodynamic printing (EHDP) has attracted extensive interests as a powerful technology to fabricate micro- to nano-scale fibrous scaffolds in a custom-tailored manner for biomedical applications. A few synthetic biopolymer inks are applicable to this EHDP technology, but the fabricated scaffolds suffered from low mechanical strength, biocompatibility, and biodegradability. In this study, a series of poly(ε-caprolactone) (PCL)/zein composite inks were developed and their printability was examined on a solution-based EHDP system for scaffold fabrication. Multilayer grid scaffolds were manufactured by PCL, PCL/zein-10, and PCL/zein-20 inks, respectively and characterized. The mechanical strength of scaffolds printed by PCL/zein composite inks was remarkably enhanced in terms of Young's modulus and yield stress. The enzyme-accelerated in vitro degradation study demonstrated that zein-containing scaffolds exhibited dose-responsive improvement on the degradation rate as evidenced by surface morphological change of fibers. Moreover, the biocompatibility of PCL/zein scaffolds, tested on mice embryonic fibroblast (NIH/3T3) and human nonsmall lung cancer cell (H1299), manifested better cell affinity. Our findings suggest that sca...Continue Reading

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Citations

Oct 20, 2019·Biomolecules·Hossein JahangirianThomas J Webster
Dec 24, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ceren KimnaFunda Tihminlioglu
Feb 13, 2021·Tissue Engineering. Part a·Hang ZhangJing Qu
Sep 10, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Xiao YuJichao Wang
Jul 2, 2021·ACS Biomaterials Science & Engineering·Jorge Alfonso Tavares-NegreteGrissel Trujillo-de Santiago

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