Zein Nanoparticles and Strategies to Improve Colloidal Stability: A Mini-Review

Frontiers in Chemistry
Mônica PascoliLeonardo F Fraceto

Abstract

Zein, a protein extracted from maize, can be employed to easily produce nanoscale particles suitable for use as carrier systems. This review investigates the main methods for obtaining zein nanoparticles, as well as the problems and options available in the development of stable colloidal suspensions. Considerable gaps were identified in the literature concerning this topic, with studies being unclear about the factors that affect the stability of zein particles. In the vast majority of cases, no data are presented in relation to the stability of the formulations over time. It could be concluded that in order to produce a high quality system, detailed evaluation is required, considering factors including the zein concentration, pH, ionic strength, thermal treatment of the protein prior to preparation of the nanoparticles, strategies employing other materials as coatings, and the storage conditions. It is extremely important that these aspects should be considered during product development, prior to commercial-scale manufacture.

References

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Citations

Mar 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Víctor Santos-RosalesCarlos A García-González
Mar 1, 2019·Gels·Ana I BourbonMiguel A Cerqueira
Mar 12, 2020·Drug Delivery·Duy Toan Pham, Waree Tiyaboonchai
May 19, 2020·Food Science and Biotechnology·Francisco Rodríguez-FélixJosé Agustín Tapia-Hernández
Nov 23, 2019·International Journal of Molecular Sciences·Nabil A AlhakamyUsama A Fahmy
Nov 20, 2020·International Journal of Biological Macromolecules·Parinaz Nezhad-MokhtariNima Abdyazdani
Feb 23, 2021·ACS Pharmacology & Translational Science·Pragya Prasanna, Arun Upadhyay
Apr 4, 2021·International Journal of Molecular Sciences·Pakama MahlumbaYahya E Choonara
Jul 3, 2021·Materials·Narendra Reddy, Marco Rapisarda
Dec 2, 2020·Biomacromolecules·Víctor Santos-RosalesAmeya Rege

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Methods Mentioned

BETA
nanoprecipitation
thermal treatment

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