Zein/gelatin/nanohydroxyapatite nanofibrous scaffolds are biocompatible and promote osteogenic differentiation of human periodontal ligament stem cells

Biomaterials Science
Qianmin OuYan Wang

Abstract

In bone tissue engineering, it is important for biomaterials to promote the osteogenic differentiation of stem cells to achieve tissue regeneration. Therefore, it is critical to develop biomaterials with excellent cytocompatibility and osteoinductive ability. In our previous study, we found a zein/gelatin electrospinning scaffold with good biocompatibility, but low osteoinductive ability for human periodontal ligament stem cells (hPDLSCs). Therefore, herein, we fabricated novel zein/gelatin/nanohydroxyapatite (zein/gelatin/nHAp) nanofibrous membranes to overcome the drawbacks of the zein/gelatin scaffold. The results showed that the surface wettability of the zein/gelatin/nHAp nanofiber membranes was increased. Moreover, the inclusion of nHAp facilitated the attachment, proliferation, and osteogenic differentiation of hPDLSCs. Overall, the zein/gelatin/nHAp nanofiber membranes showed good biocompatibility and osteoinductive activity for hPDLSCs in vitro and in vivo; this suggested potential applications of these membranes in bone tissue engineering.

References

Feb 27, 2004·Journal of Biomedical Materials Research. Part a·A R El-GhannamR J Composto
Jun 15, 2012·Biomaterials·Fa-Ming ChenQing Yu
Mar 19, 2013·Materials Science & Engineering. C, Materials for Biological Applications·Pelagie M FaviMadhu S Dhar
Oct 12, 2013·Australian Dental Journal·J HanP M Bartold
Jun 10, 2016·ACS Applied Materials & Interfaces·Yu FuYan-Heng Zhou
Aug 3, 2016·Acta Biomaterialia·Zheng-Zheng ZhangJia-Kuo Yu
Sep 7, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Marta RibeiroHaritz Sardon
Dec 10, 2016·Journal of Biomaterials Science. Polymer Edition·Bingjie NiuLiang Chen
Dec 19, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Cai ZhijiangLiu Yuanpei
May 31, 2017·Nanomedicine : Nanotechnology, Biology, and Medicine·Shige WangXiangyang Shi
Jun 10, 2017·Biomaterials Science·G M L DalmônicoM Canillas
Sep 6, 2017·Journal of Tissue Engineering and Regenerative Medicine·S BabithaPurna Sai Korrapati
Sep 10, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Jun LinYiwang Chen
Sep 30, 2017·Biomaterials Science·Jie WuJingbo Yin
Feb 9, 2018·Nanomedicine·Rafał PokrowieckiAgnieszka Mielczarek
Mar 7, 2018·Journal of Biological Physics·Ágata PaimPatricia Pranke
Sep 7, 2018·ACS Applied Materials & Interfaces·Jeong Eun SongGilson Khang
Nov 15, 2018·Materials Science & Engineering. C, Materials for Biological Applications·Li HuangYaopeng Zhang
Nov 18, 2018·International Journal of Biological Macromolecules·Claudia SanhuezaRodrigo Navia

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Citations

Mar 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Honghai LiGeng Yang
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nicola d'AvanzoMassimo Fresta

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Methods Mentioned

BETA
Assay
fluorescence microscopy
flow cytometry
PCR

Software Mentioned

Image Plus
LightCycler 480
SPSS
FlowJo
Mimics

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