Zein/polycaprolactone electrospun matrices for localised controlled delivery of tetracycline

Drug Delivery and Translational Research
Nour AlhuseinPaul A De Bank

Abstract

We report the controlled release of the antibiotic tetracycline (Tet) from triple-layered (3L) electrospun matrices consisting of zein or a zein/PCL blend, where the drug was loaded into the central layer with the two outer layers acting as diffusion barriers. These fibrous matrices successfully encapsulated Tet and efficiently inhibited the growth of a clinical isolate, the methicillin-resistant Staphylococcus aureus strain MRSA252, as demonstrated in a modified Kirby-Bauer disc assay over 5 days. Whilst untreated zein fibres are unstable in an aqueous environment, rapidly shrinking due to plasticisation and film formation, blending zein with PCL stabilised the electrospun matrices and prevented them from shrinking. These 3L formulations display sustained antibiotic release and provide a proof of concept for zein-based polymeric matrices as wound dressings to treat or prevent bacterial infection. This is the first demonstration of the controlled release of a clinically used antibiotic from electrospun zein-based matrices.

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Citations

Oct 16, 2014·Molecular Pharmaceutics·Felipe L LopezGareth R Williams
Feb 28, 2015·Advanced Healthcare Materials·Mohammad NorouziMasoud Soleimani
Aug 24, 2016·Journal of the Mechanical Behavior of Biomedical Materials·Bikendra MaharjanCheol Sang Kim
Jan 28, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Marina CraigKrister Holmberg
Aug 23, 2019·IET Nanobiotechnology·Amin MonfaredSomayeh Ebrahimi-Barough
Dec 28, 2018·Pharmaceutics·Laura Modica de MohacBahijja Tolulope Raimi-Abraham

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