Zeolitic Imidazolate framework-8 as efficient pH-sensitive drug delivery vehicle

Dalton Transactions : an International Journal of Inorganic Chemistry
Chun-Yi SunEn-Bo Wang

Abstract

Zeolitic Imidazolate Framework-8 (ZIF-8), for the first time for ZIFs, exhibits a remarkable capacity for the anticancer drug 5-fluorouracil (5-FU), around 660 mg of 5-FU/g of ZIF-8, and presents a pH-triggered controlled drug release property. These prove ZIF-8 to be a valuable candidate for delivery of anticancer agents and reveal its potential applications in the treatment of cancer.

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Citations

Feb 18, 2016·Inorganic Chemistry·Sara RojasElisa Barea
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