Zero-order release of aspirin, theophylline and atenolol in water from novel methylcellulose glutarate matrix tablets

International Journal of Pharmaceutics
A KhairuzzamanN K Patel

Abstract

A novel hydrocolloidal polymer, methylcellulose glutarate (MC-GA), was prepared by esterifying methylcellulose with glutaric anhydride. The formation of ester was confirmed by FTIR and NMR spectroscopy, DSC and elemental analysis. The physicochemical properties such as, rate of swelling in water, viscosity and hygroscopicity of MC-GA were determined and compared with those of methycellulose A (MC). Aspirin, theophylline and atenolol tablets were compacted on a Carver press using the wet granulation method. Each tablet contained: 200 mg active, 80 mg anhydrous lactose, 8 mg povidone, 4 mg magnesium stearate, 4 mg talc, 50mg MC or MC-GA (drug-to-polymer ratio, 4:1). Contrary to the first-order release profile of all the drugs from the MC matrix tablets, a zero-order release was obtained from the MC-GA matrix tablets in water.

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Citations

Aug 26, 2015·International Journal of Pharmaceutics·Thawatchai Phaechamud, Jongjan Mahadlek
Feb 3, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Pornsak SriamornsakKingkarn Korkerd
Nov 9, 2016·International Journal of Pharmaceutics·Jinlong ZhaoYouxin Li
Oct 24, 2009·Pharmaceutical Development and Technology·Zsófia FenyvesiSylvia Marton
May 14, 2021·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Setthapong SenaratThawatchai Phaechamud

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