Zerumbone suppresses the potential of growth and metastasis in hepatoma HepG2 cells via the MAPK signaling pathway

Oncology Letters
Tao LvXiaoli Han

Abstract

Zerumbone is an active component of Zingiber zerumbet (L.) Smith and can perform a diverse range of antitumor activities. However, the underlying molecular mechanisms of zerumbone action have not yet been elucidated. The aim of the present study was to investigate the antitumor effects, and the associated molecular mechanisms, of zerumbone in hepatoma HepG2 cells. Treatment with zerumbone markedly induced apoptosis in hepatoma HepG2 cells and suppressed their invasion and metastasis in a dose-dependent manner. Further investigation revealed that treatment with zerumbone led to the dose-dependent induction of apoptosis and cell cycle arrest at G2/M phase in cancer cells. Zerumbone treatment led to the increased expression of p27, cytochrome c, caspase-3 and-9, and Bcl-2-associated X expression, but the decreased expression of cyclin-dependent kinase 1, cyclin B1, B-cell lymphoma-2, focal adhesion kinase, Ras homolog gene family, member A, Rho-associated protein kinase-1, and matrix metalloproteinase-2 and-9 in HepG2 cells. In addition, the phosphorylation of p38 mitogen-activated protein kinase and extracellular signal-regulated kinase 1/2, but not C-Jun N-terminal kinase 1/2, was regulated in a dose-dependent manner in response...Continue Reading

Citations

Feb 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sosmitha GirisaAjaikumar B Kunnumakkara
Aug 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·John F Lechner, Gary D Stoner
May 27, 2020·Oxidative Medicine and Cellular Longevity·Mohammad Jalili-NikAmirhossein Sahebkar
Jun 8, 2021·Critical Reviews in Food Science and Nutrition·Sajad FakhriHaroon Khan

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Methods Mentioned

BETA
PCR
flow cytometry
GTPase

Software Mentioned

SPSS

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