Zhangfei induces the expression of the nerve growth factor receptor, trkA, in medulloblastoma cells and causes their differentiation or apoptosis.

Journal of Neuro-oncology
Ximena ValderramaVikram Misra

Abstract

Interactions between nerve growth factor (NGF) and its receptor-the tropomyosin related kinase A (trkA)-regulate many neuronal functions including the correct development of sensory neurons during embryogenesis, the survival of sensory neurons and the differentiation and apoptosis of neuronal tumours. Zhangfei is a transcriptional factor that is expressed in differentiated neurons. Since we could detect Zhangfei in mature neurons but not in neuronal tumour cells, we hypothesised that ectopic expression of the protein in medulloblastoma cells may induce the differentiation of these cells. We show that in ONS-76 medulloblastoma cells, resveratrol, an inducer of apoptosis and differentiation, increased the expression of Zhangfei, trkA and Early Growth Response Gene 1 (Egr1), a gene normally activated by NGF-trkA signalling. ONS-76 cells stopped growing soon after treatment with resveratrol. While the induction of Zhangfei in resveratrol-treated cells was modest albeit consistent, the infection of actively growing medulloblastoma cells with an adenovirus vector expressing Zhangfei mimicked some of the effects of resveratrol. Ectopically expressed Zhangfei in ONS-76 cells led to the increased expression of trkA and Egr1, phosphoryla...Continue Reading

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Citations

Jan 24, 2014·PloS One·Cátia PintoAna C Gomes
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May 28, 2019·Journal of Cellular Physiology·Minjie LuPengfei Lin
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Dec 12, 2013·Reproductive Biology and Endocrinology : RB&E·Pengfei LinAihua Wang
Dec 23, 2009·Biochemical and Biophysical Research Communications·Yani ZhangRui Lu
Jan 13, 2019·Scientific Reports·Shaoshuai LiangZhenkui Qin

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