Zic2 hypomorphic mutant mice as a schizophrenia model and ZIC2 mutations identified in schizophrenia patients.

Scientific Reports
Minoru HatayamaJun Aruga

Abstract

ZIC2 is a causal gene for holoprosencephaly and encodes a zinc-finger-type transcriptional regulator. We characterized Zic2(kd/+) mice with a moderate (40%) reduction in Zic2 expression. Zic2(kd/+) mice showed increased locomotor activity in novel environments, cognitive and sensorimotor gating dysfunctions, and social behavioral abnormalities. Zic2(kd/+) brain involved enlargement of the lateral ventricle, thinning of the cerebral cortex and corpus callosum, and decreased number of cholinergic neurons in the basal forebrain. Because these features are reminiscent of schizophrenia, we examined ZIC2 variant-carrying allele frequencies in schizophrenia patients and in controls in the Japanese population. Among three novel missense mutations in ZIC2, R409P was only found in schizophrenia patients, and was located in a strongly conserved position of the zinc finger domain. Mouse Zic2 with the corresponding mutation showed lowered transcription-activating capacity and had impaired target DNA-binding and co-factor-binding capacities. These results warrant further study of ZIC2 in the pathogenesis of schizophrenia.

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Citations

Jan 7, 2016·Scientific Reports·Yong XuDai Zhang
Oct 17, 2017·Glia·Min LiuSanbing Shen
Oct 19, 2017·Human Molecular Genetics·Hiroyuki MiyamotoKazuhiro Yamakawa
Jul 29, 2020·Nature Neuroscience·Takashi YamaguchiDayu Lin
Oct 3, 2013·Molecular Autism·Travis M KerrJeremy Veenstra-Vanderweele

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Methods Mentioned

BETA
electrophoresis
immunoprecipitation
transgenic
PCR

Software Mentioned

Paravision
MATLAB
PolyPhen
InsightITK
- Snap
Statistical Parametric Mapping ( SPM )
PolyPhen Polyphen

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