PMID: 9170413Apr 15, 1997Paper

Zidovudine potentiates local and systemic inflammatory responses in the rat

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association
P RaymondA Adam

Abstract

The effect of chronic treatment with zidovudine (AZT) on the inflammatory response was examined in the rat. AZT was administered orally for 36 days. On day 35, inflammation was induced by hindpaw injection of 1% carrageenan lambda. Paw edema over a 24-hour period was used as a marker of the local inflammatory reaction. On day 36, quantification of immunoreactive T-kininogen and alpha 1-inhibitor-3 in liver and serum was used to assess the systemic inflammatory response. Albumin was selected as a protein whose concentration is modified only slightly or not at all during the acute-phase response. Animals treated with AZT transiently exhibited significantly greater (18%) paw edema 3 hours after carrageenan injection. AZT treatment alone induced a 1.8-fold increase in serum T-kininogen concentration, but it had no effect on albumin and alpha 1-inhibitor-3. In rats with inflamed paws, AZT administration led to a significant increase in liver (3.4-fold) and serum (1.8-fold) immunoreactive T-kininogen content. Dot blot analysis of total RNA isolated from liver correlated with the protein measurements. Our results indicate that chronic treatment with AZT potentiates the nonspecific local and the systemic inflammatory responses in the rat.

References

Aug 1, 1978·Hoppe-Seyler's Zeitschrift für physiologische Chemie·F Gauthier, K Ohlsson
Aug 1, 1975·The Journal of Pharmacy and Pharmacology·J M Hall, C Hallett
Jul 1, 1991·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·M B ThompsonJ D Prejean
Apr 1, 1990·Molecular Endocrinology·K P Anderson, J B Lingrel
Aug 22, 1991·Biochemical Pharmacology·S C SikkaK C Agrawal
Aug 1, 1990·Metabolism: Clinical and Experimental·T P SteinM J Leskiw
May 1, 1988·European Journal of Immunology·T GeigerP C Heinrich
Dec 1, 1988·Inflammation·F A De JongG Schreiber
Feb 1, 1989·Journal of Interferon Research·W J Richtsmeier, S E Grossberg
Dec 1, 1989·Molecular and Cellular Biology·F SierraY Guigoz
Feb 1, 1989·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·A AdamV Bourdon
Sep 1, 1989·Gene·K P AndersonJ B Lingrel
May 1, 1985·Molecular and Cellular Biology·P DesjardinsR Morais
Apr 5, 1988·European Journal of Biochemistry·T MoreauF Gauthier
Sep 16, 1969·Biochimica Et Biophysica Acta·R Morais
Aug 28, 1969·Journal of Molecular Biology·E ZylberS Penman
Jul 1, 1983·Antimicrobial Agents and Chemotherapy·J M WalG F Bories
Jan 1, 1983·Methods in Enzymology·G L Peterson
Jul 1, 1980·Circulation Research·S WallensteinJ L Fleiss
Feb 1, 1994·Immunology Today·H Baumann, J Gauldie
May 24, 1995·Biochimica Et Biophysica Acta·A W LinnaneP Nagley
Sep 7, 1995·The New England Journal of Medicine·D R Johns
Aug 24, 1995·Biochemical and Biophysical Research Communications·C V Oddis, M S Finkel
Jan 1, 1994·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·P Lestienne, N Bataillé
Apr 1, 1994·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·D J Morris
Jun 1, 1994·Journal of Bioenergetics and Biomembranes·D C Wallace
Jul 15, 1993·Biochemical and Biophysical Research Communications·J S Modica-Napolitano
Feb 1, 1996·Pathology, Research and Practice·T CorcueraA López-Bravo
Aug 1, 1996·The Journal of Experimental Medicine·H HerwaldL Björck
Oct 13, 1995·Mechanisms of Ageing and Development·F Sierra

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