PMID: 2492585Jan 1, 1989Paper

Zidovudine treatment of patients with acquired immune deficiency syndrome and acquired immune deficiency syndrome-related complex: St Stephen's Hospital experience

The Journal of Infection
D StambukB G Gazzard

Abstract

Zidovudine was used in an open uncontrolled study for treatment of 145 human immunodeficiency virus (HIV) patients, 102 with acquired immune deficiency syndrome (AIDS) and 43 with symptomatic HIV disease (acquired immune deficiency syndrome related-complex, ARC). The mean period of follow-up was 6 +/- 2.5 months. The median survival time of AIDS patients on zidovudine was 4.5 times longer when compared to a historical zidovudine untreated AIDS group (1657 vs. 370 days). This should be interpreted with reserve regarding improvements in treatment of all aspects of HIV infection and heightened awareness of AIDS which may have led to earlier diagnosis in the zidovudine treated groups. Pneumocystis carinii pneumonia (PCP) was very rarely a cause of death in zidovudine-treated patients (4.8%), while it was responsible for the death in 46.2% of historical controls (P less than 0.001). Extensive Kaposi's sarcoma was equally the cause of death in treated as well as in historical patients. Median T4 cell counts increased on zidovudine reaching a peak at the end of the fourth month of therapy in the ARC group and at the end of the first month in the AIDS group with a subsequent fall. Sixty per cent (53 of 87) patients were p24 viral antig...Continue Reading

References

May 1, 1988·Gut·G M ConnollyB G Gazzard

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Citations

Jul 1, 1996·Journal of the American Academy of Nurse Practitioners·B Wise
Oct 23, 2019·Frontiers in Immunology·Christina GavegnanoVincent C Marconi
Jul 1, 1996·Scandinavian Journal of Gastroenterology·J L YuA Ljungh
Jan 1, 1990·Clinical and Laboratory Haematology·S G LimP B Kernoff

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