ZIF-C for targeted RNA interference and CRISPR/Cas9 based gene editing in prostate cancer.

Chemical Communications : Chem Comm
Arpita PoddarRavi Shukla

Abstract

Gene therapy is highly suited for prostate cancer (PC). Metal-organic-frameworks (MOFs) are potential gene delivery systems. Target-specific cytoplasmic and nuclear knockdown in host gene expression using ZIF-C is shown for the first time through RNAi and CRISPR/Cas9 based gene editing in PC cells. A green tea phytochemical coating enhances intracellular delivery.

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Citations

Jul 15, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Namita SinghNiveen M Khashab
Jul 30, 2021·Advanced Drug Delivery Reviews·Xiaoyu XuHongbo Zhang
Oct 30, 2021·Chemical Communications : Chem Comm·Pei-Hong TongTony D James

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Methods Mentioned

BETA
transfection
electrophoresis
X-Ray
scanning electron microscopy
PCR
gene knock down

Software Mentioned

ANAT

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