Feb 19, 2016

ZIKA - How Fast Does This Virus Mutate ?

BioRxiv : the Preprint Server for Biology
Ian S Logan


The World Health Organisation has declared the present epidemic of infection with the Zika virus to be a Public Health Emergency of International Concern. The virus appears to have spread from Thailand to French Polynesia in 2013, and has since infected over a million people in the countries of South and Central America. In most cases the infection is mild and transient, but the virus does appear to be strongly neurotropic and the presumptive cause of both birth defects in foetuses and Guillain-Barr&eacute syndrome in some adults. In this paper the techniques and utilities developed in the study of mitochondrial DNA are applied to the Zika virus. As a result it is possible to show in a simple manner how a phylogenetic tree may be constructed and how the mutation rate of the virus can be measured. The study shows the mutation rate to vary between 12 and 25 bases a year, in a viral genome of 10,272 bases. This rapid mutation rate will enable the geographic spread of the epidemic to be monitored easily and may also prove useful in assisting the identification of preventative measures that are working, and those which are not.

  • References
  • Citations


  • We're still populating references for this paper, please check back later.
  • References
  • Citations


  • This paper may not have been cited yet.

Mentioned in this Paper

Viral Genome Location
Trees (plant)
DNA, Mitochondrial
Neuropharmacologic agent
World Health Organization

About this Paper

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Related Papers

Emerging Infectious Diseases
W Thane HancockMartin Bel
Emerging Infectious Diseases
Van-Mai Cao-LormeauDidier Musso
Jean-Marie JouannicDominique Eyrolle-Guignot
Current Opinion in Infectious Diseases
Guilherme Amaral CalvetPatricia Carvalho Sequeira
© 2020 Meta ULC. All rights reserved