Zika and Chikungunya Virus and Risk for Venous Thromboembolism

Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Eduardo RamacciottiJawed Fareed

Abstract

A variety of viral infections are associated with hypercoagulable states and may be linked to the development of deep venous thrombosis and pulmonary embolism. The Zika and Chikungunya viral infections spread through the South and Central American continents, moving to North America in 2016, with severe cases of polyarthralgia, fever, and Guillain-Barré syndrome leading eventually to death. A decreased trend for both infections was reported in the first quarter of 2017. In this article, we report the possible association of venous thromboembolic events associated with Zika infection. After 2 cases of deep venous thrombosis in patients with acute Zika infections, D-dimer levels were measured in 172 consecutive patients who presented to the emergency department of a university hospital in an endemic region of Brazil with either Zika or Chikungunya infections confirmed by polymerase chain reaction tests. D-dimer levels were increased in 19.4% of 31 patients with Zika and in 63.8% of 141 patients with Chikungunya infections. The mechanisms behind this association are yet to be elucidated as well as the potential for venous thromboembolism prevention strategies for in-hospital patients affected by Zika and Chikungunya infections.

References

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Citations

May 15, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Job Harenberg, Emmanuel Favaloro
Jul 11, 2020·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Eduardo RamacciottiJawed Fareed
Jul 20, 2019·Jornal Vascular Brasileiro·Marcos Arêas MarquesHenrique Jorge Guedes
Jul 12, 2020·Nature Medicine·Aakriti GuptaDonald W Landry
Aug 15, 2020·Oxford Medical Case Reports·Sarah DjebaraPeter Vanbrabant
Aug 21, 2020·Journal of Thrombosis and Thrombolysis·Sarah K Adie, Nicholas Farina
Jul 21, 2020·Research and Practice in Thrombosis and Haemostasis·Edward L G PryzdialMarc Horwitz
Jun 23, 2020·Clinical Hemorheology and Microcirculation·Romeo Martini
Jul 18, 2020·Frontiers in Physiology·Antonio ColantuoniGregorio Caimi
Jun 4, 2020·Journal of Clinical Medicine·Benjamin MarchandotOlivier Morel
Sep 13, 2020·The American Journal of Tropical Medicine and Hygiene·Aveek MukherjeeMarlene Marte Furment
Nov 28, 2020·Vascular Health and Risk Management·Roberto ChalelaDiego A Rodríguez-Chiaradía
Jan 1, 2021·Cell & Bioscience·Miriam Marlene Medina-EnríquezTalia Wegman-Ostrosky
Apr 21, 2020·Journal of the American College of Cardiology·Behnood BikdeliUNKNOWN Global COVID-19 Thrombosis Collaborative Group, Endorsed by the ISTH, NATF, ESVM, and the IUA, Supported by the ESC Working
Mar 7, 2021·Journal of Clinical Medicine·Matthijs RaadsenMarco Goeijenbier
Jun 29, 2021·Jornal Vascular Brasileiro·Marcone Lima Sobreira, Marcos Arêas Marques
Jul 3, 2021·Jornal Vascular Brasileiro·Julio Cesar Peclat de OliveiraBianca Gutfilen
Dec 7, 2020·Trends in Cardiovascular Medicine·Manuel Martínez-Sellés

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Methods Mentioned

BETA
PCR
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

Power

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