Zika in Rio de Janeiro: Assessment of basic reproduction number and comparison with dengue outbreaks

Epidemiology and Infection
Daniel A M VillelaClaudia Torres Codeco


Zika virus infection was declared a public health emergency of international concern in February 2016 in response to the outbreak in Brazil and its suspected link with congenital anomalies. In this study, we use notification data and disease natural history parameters to estimate the basic reproduction number (R 0) of Zika in Rio de Janeiro, Brazil. We also obtain estimates of R 0 of dengue from time series of dengue cases in the outbreaks registered in 2002 and 2012 in the city, when DENV-3 and DENV-4 serotypes, respectively, had just emerged. Our estimates of the basic reproduction number for Zika in Rio de Janeiro based on surveillance notifications (R 0 = 2·33, 95% CI: 1·97-2·97) were higher than those obtained for dengue in the city (year 2002: R 0 = 1·70 [1·50-2·02]; year 2012: R 0 = 1·25 [1·18-1·36]). Given the role of Aedes aegypti as vector of both the Zika and dengue viruses, we also derive R 0 of Zika as a function of both dengue reproduction number and entomological and epidemiological parameters for dengue and Zika. Using the dengue outbreaks from previous years allowed us to estimate the potential R 0 of Zika. Our estimates were closely in agreement with our first Zika's R 0 estimation from notification data. Henc...Continue Reading


Oct 13, 2018·PloS One·Marcio M Bastos, Flavio Codeço Coelho
Dec 18, 2018·PLoS Neglected Tropical Diseases·Warren Tennant, Mario Recker
Jan 23, 2019·PLoS Medicine·Aubree GordonEva Harris
Jan 29, 2020·PloS One·Esteban Dodero-RojasVinícius G Contessoto
Sep 29, 2020·PLoS Neglected Tropical Diseases·Sean M MooreT Alex Perkins
Aug 4, 2018·Computational and Mathematical Methods in Medicine·Marcos AmakuE Massad
Aug 1, 2019·Epidemiology and Infection·E MassadAnnelies Wilder-Smith


Mar 12, 1987·Nature·R M May, R M Anderson
Jul 11, 2001·Theoretical Population Biology·T CaracoB K Szymanski
Oct 3, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·E MassadL F Lopez
Oct 31, 2001·Memórias do Instituto Oswaldo Cruz·R M NogueiraH G Schatzmayr
Sep 1, 1952·Transactions of the Royal Society of Tropical Medicine and Hygiene·G W A DICKA J HADDOW
Mar 3, 2007·The Journal of Infectious Diseases·Hiroshi Nishiura, Scott B Halstead
Nov 17, 2010·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·S T R PinhoM G L Teixeira
Jun 10, 2011·Memórias do Instituto Oswaldo Cruz·Rita M R Nogueira, Ana L F Eppinghaus
Dec 12, 2012·PloS One·Miranda Chan, Michael A Johansson
May 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Minh Nguyen NguyetCameron P Simmons
Jan 28, 2015·Emerging Infectious Diseases·Didier MussoVan-Mai Cao-Lormeau
Apr 24, 2015·PLoS Neglected Tropical Diseases·Heverton Leandro Carneiro DutraLuciano Andrade Moreira
Feb 4, 2016·BMJ : British Medical Journal·Anne Gulland
Feb 11, 2016·The New England Journal of Medicine·Jernej MlakarTatjana Avšič Županc
Feb 22, 2016·The Lancet Infectious Diseases·Guilherme A CalvetAna M B de Filippis
Feb 24, 2016·The American Journal of Tropical Medicine and Hygiene·Rebecca C Christofferson
Mar 1, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Hiroshi NishiuraKyeongah Nah
Mar 2, 2016·Journal of Infection in Developing Countries·Jorg HeukelbachLuciano Pamplona de Góes Cavalcanti
Mar 5, 2016·PLoS Neglected Tropical Diseases·Thais Chouin-CarneiroAnna-Bella Failloux
Mar 5, 2016·The New England Journal of Medicine·Patrícia BrasilKarin Nielsen-Saines
Mar 26, 2016·Science·Nuno Rodrigues FariaPedro F C Vasconcelos
Apr 14, 2016·The New England Journal of Medicine·Eric D'OrtenzioIsabelle Leparc-Goffart
Jun 18, 2016·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Christina FrankDennis Tappe
Jun 18, 2016·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Thomas FréourIsabelle Leparc-Goffart
Jul 13, 2016·The American Journal of Tropical Medicine and Hygiene·Rosalind E HowesSimon I Hay
Jul 16, 2016·Science·Neil M FergusonJustin Lessler
Sep 7, 2016·PLoS Neglected Tropical Diseases·Rosilainy Surubi FernandesRicardo Lourenço-de-Oliveira
Sep 25, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Flavio Codeço CoelhoMargaret Armstrong
Sep 28, 2016·The Lancet Infectious Diseases·Laith YakobW John Edmunds
Oct 6, 2016·Memórias do Instituto Oswaldo Cruz·Anielly Ferreira-de-BritoRicardo Lourenço-de-Oliveira
Nov 9, 2016·Bulletin of the World Health Organization·Justin LesslerLelia H Chaisson
Dec 8, 2016·PLoS Neglected Tropical Diseases·Sebastian FunkW John Edmunds

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