ZIKA Virus and Neuroscience: the Need for a Translational Collaboration

Molecular Neurobiology
Lavínia Schuler-FacciniDiogo O Souza


Zika virus (ZIKV) has become a major challenge for scientists and health agencies. ZIKV's involvement with human fetal microcephaly and Guillain-Barré syndrome and its transmission through Aedes africanus and Aedes aegypti mosquitos highlighted the epidemiological and neurological risks associated to ZIKV infection. In 2013, ZIKV arrives in Brazil but the first outbreak in the country was reported in 2015. Here, we used the Web of Science as a search tool for comparing the evolution of world and Brazilian scientific research on dengue virus (DENV)-also present in mosquito-, ZIKV and microcephaly. The association between ZIKV and microcephaly was only evidenced in 2015. Interestingly, Brazil and the USA are the responsible for most of these reports. Furthermore, the level of double-counted articles indicates a high degree of international collaborative effort in studying ZIKV and microcephaly. The ZIKV research clearly requires multidisciplinary expertise including epidemiologic, clinical, virological, and neurochemical backgrounds. This letter intends to emphasize the need of multidisciplinary studies and put forward some as yet unanswered questions in attempting to contribute to the understanding of this multifaceted health pr...Continue Reading


Sep 1, 1952·Transactions of the Royal Society of Tropical Medicine and Hygiene·G W A DICKA J HADDOW
Dec 7, 2007·PLoS Neglected Tropical Diseases·Colin D MathersAlan D Lopez
Nov 20, 2015·Emerging Infectious Diseases·Cristiane W CardosoGuilherme S Ribeiro
Jan 14, 2016·The New England Journal of Medicine·Anthony S Fauci, David M Morens
Jan 29, 2016·MMWR. Morbidity and Mortality Weekly Report·Lavínia Schuler-FacciniBrazilian Medical Genetics Society–Zika Embryopathy Task Force
Feb 11, 2016·The New England Journal of Medicine·Jernej MlakarTatjana Avšič Županc
Mar 24, 2016·Trends in Cell Biology·Jeffrey L Frost, Dorothy P Schafer
Mar 26, 2016·Science·Nuno Rodrigues FariaPedro F C Vasconcelos
Apr 4, 2016·Cell Stem Cell·Tomasz J NowakowskiArnold R Kriegstein
Apr 12, 2016·Science·Patricia P GarcezStevens K Rehen
Apr 14, 2016·The New England Journal of Medicine·Sonja A RasmussenLyle R Petersen
Apr 27, 2016·Lancet·Patrícia BrasilT Solomon
Jun 25, 2016·Nature·Giovanna Barba-SpaethFelix A Rey
Jun 25, 2016·Nature Immunology·Wanwisa DejnirattisaiGavin R Screaton
Jun 30, 2016·Lancet·Leonelo E Bautista, Ajay K Sethi
Jun 30, 2016·Proceedings of the National Academy of Sciences of the United States of America·Lalita PriyamvadaJens Wrammert
Jul 2, 2016·Journal of Infection in Developing Countries·Luciano Pamplona De Góes CavalcantiJorg Heukelbach


Sep 13, 2019·Journal of Neurovirology·Rafael L RosaWalter O Beys-da-Silva
Aug 12, 2017·Frontiers in Microbiology·Irfan A RatherJeongheui Lim
Jul 10, 2018·The Nurse Practitioner·Versie Johnson-MallardNancy Fugate Woods
Feb 11, 2021·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Natalia AragónAdolfo Contreras

Related Concepts

Dengue Virus
Guillain-Barre Syndrome
Health Systems Agencies
Disease Transmission
Zika virus (organism)
Aedes aegypti
Health/Scientific Organization
Research in General