Zika virus encephalitis in immunocompetent mice is dominated by innate immune cells and does not require T or B cells

Journal of Neuroinflammation
Emina HayashidaMarkus Hofer

Abstract

Until the end of the twentieth century, Zika virus (ZIKV) was thought to cause a mostly mild, self-limiting disease in humans. However, as the geographic distribution of ZIKV has shifted, so too has its pathogenicity. Modern-day ZIKV infection is now known to cause encephalitis, acute disseminated encephalomyelitis, and Guillain-Barré syndrome in otherwise healthy adults. Nevertheless, the underlying pathogenetic mechanisms responsible for this shift in virulence remain unclear. Here, we investigated the contribution of the innate versus the adaptive immune response using a new mouse model involving intracranial infection of adult immunocompetent mice with a moderately low dose of ZIKV MR766. To determine the contribution of type I interferons (IFN-Is) and adaptive immune cells, we also studied mice deficient for the IFN-I receptor 1 (Ifnar1-/-) and recombination-activating gene 1 (Rag1-/-). We show that intracranial infection with ZIKV resulted in lethal encephalitis. In wild-type mice, ZIKV remained restricted predominantly to the central nervous system (CNS) and infected neurons, whereas astrocytes and microglia were spared. Histological and molecular analysis revealed prominent activation of resident microglia and infiltrat...Continue Reading

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Citations

Sep 26, 2020·Frontiers in Immunology·Loulieta NazeraiAllan Randrup Thomsen
Aug 14, 2020·Current Opinion in Virology·Carlos Diaz-Salazar, Joseph C Sun

Datasets Mentioned

BETA
KU963574.2

Methods Mentioned

BETA
flow cytometry

Related Concepts

Zika Virus Disease (Disorder)
Zika virus (organism)
Metazoa
B-Lymphocytes
Resistance, Natural
Mice, Inbred C57BL
T-Lymphocyte
Mice, Knockout
Viral Encephalitis
Mouse, Swiss

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