Zika virus encephalitis in immunocompetent mice is dominated by innate immune cells and does not require T or B cells

Journal of Neuroinflammation
Emina HayashidaMarkus Hofer


Until the end of the twentieth century, Zika virus (ZIKV) was thought to cause a mostly mild, self-limiting disease in humans. However, as the geographic distribution of ZIKV has shifted, so too has its pathogenicity. Modern-day ZIKV infection is now known to cause encephalitis, acute disseminated encephalomyelitis, and Guillain-Barré syndrome in otherwise healthy adults. Nevertheless, the underlying pathogenetic mechanisms responsible for this shift in virulence remain unclear. Here, we investigated the contribution of the innate versus the adaptive immune response using a new mouse model involving intracranial infection of adult immunocompetent mice with a moderately low dose of ZIKV MR766. To determine the contribution of type I interferons (IFN-Is) and adaptive immune cells, we also studied mice deficient for the IFN-I receptor 1 (Ifnar1-/-) and recombination-activating gene 1 (Rag1-/-). We show that intracranial infection with ZIKV resulted in lethal encephalitis. In wild-type mice, ZIKV remained restricted predominantly to the central nervous system (CNS) and infected neurons, whereas astrocytes and microglia were spared. Histological and molecular analysis revealed prominent activation of resident microglia and infiltrat...Continue Reading


Mar 6, 1992·Cell·P MombaertsV E Papaioannou
Oct 6, 1997·Journal of Virology·V C Asensio, Iain L Campbell
Sep 1, 1952·Transactions of the Royal Society of Tropical Medicine and Hygiene·G W A DICKA J HADDOW
Sep 1, 1952·Transactions of the Royal Society of Tropical Medicine and Hygiene·G W A DICK
Sep 15, 2007·Journal of Neurochemistry·Daniel R GettsNicholas J C King
Sep 10, 2008·The Journal of Experimental Medicine·Daniel R GettsNicholas J C King
Jun 12, 2009·The New England Journal of Medicine·Mark R DuffyEdward B Hayes
Dec 14, 2011·Journal of Neurosurgery·Kenichiro IwamiToshihiko Wakabayashi
Oct 23, 2012·Cell Host & Microbe·Laurent MeertensAli Amara
Dec 24, 2013·Nature Reviews. Immunology·Lionel B Ivashkiv, Laura T Donlin
Jan 13, 2015·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Sofie Van GassenYvan Saeys
Jan 24, 2015·Nature Reviews. Immunology·Finlay McNabAnne O'Garra
Dec 15, 2015·Nature Reviews. Rheumatology·Georg SchettBernhard Manger
Feb 16, 2016·Lancet·David L HeymannK U Menon
Mar 5, 2016·The New England Journal of Medicine·Patrícia BrasilKarin Nielsen-Saines
Mar 8, 2016·Lancet·Hugh J WillisonPieter A van Doorn
Mar 10, 2016·The New England Journal of Medicine·Guillaume CarteauxArmand Mekontso Dessap
Mar 11, 2016·MMWR. Morbidity and Mortality Weekly Report·Wanderson Kleber de OliveiraGiovanny Vinícius Araújo de França
Mar 30, 2016·The American Journal of Tropical Medicine and Hygiene·Shannan L RossiScott C Weaver
Apr 4, 2016·Cell Stem Cell·Tomasz J NowakowskiArnold R Kriegstein
Apr 14, 2016·Cell Host & Microbe·Helen M LazearMichael S Diamond
Apr 20, 2016·PLoS Neglected Tropical Diseases·Matthew T AliotaJorge E Osorio
May 22, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Rengina Vorou
May 24, 2016·Nature Reviews. Microbiology·Ursula Hofer
May 24, 2016·Cell Host & Microbe·Alesha GrantAdolfo Garcia-Sastre
Jun 10, 2016·Scientific Reports·Tsung-Ting TsaiChiou-Feng Lin
Jun 28, 2016·DNA and Cell Biology·David OlagnierJohn Hiscott
Jun 30, 2016·Lancet·Leonelo E Bautista, Ajay K Sethi
Sep 1, 2016·The New England Journal of Medicine·Thais Dos SantosMarcos A Espinal
Sep 7, 2016·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Cristiane N SoaresTom Solomon
Oct 6, 2016·The New England Journal of Medicine·Beatriz ParraCarlos A Pardo
Oct 13, 2016·MBio·John H-O PetterssonXavier de Lamballerie
Nov 1, 2016·EMBO Reports·Anil KumarTom C Hobman
Nov 1, 2016·Nature·Jennifer GoveroMichael S Diamond
Nov 29, 2016·European Neurology·Bruno NiemeyerEdson Marchiori
Jan 27, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anthony N van den PolJohn N Davis
Jan 28, 2017·Scientific Reports·Kjersti M AagaardRebecca Rico-Hesse
Mar 24, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Clayton W WinklerKarin E Peterson
Apr 20, 2017·Cell Reports·Andrew K HastingsAkiko Iwasaki
May 26, 2017·PLoS Pathogens·Sydney M NguyenThaddeus G Golos
Jun 6, 2017·Trends in Microbiology·Nicholas J C KingSuresh Mahalingam
Aug 25, 2017·Journal of Virology·Huarong HuangFuping Zhang
May 11, 2018·Cell Host & Microbe·Matthew J GormanMichael S Diamond


Sep 26, 2020·Frontiers in Immunology·Loulieta NazeraiAllan Randrup Thomsen
Aug 14, 2020·Current Opinion in Virology·Carlos Diaz-Salazar, Joseph C Sun

Datasets Mentioned


Methods Mentioned

flow cytometry

Related Concepts

Zika Virus Disease (Disorder)
Zika virus (organism)
Resistance, Natural
Mice, Inbred C57BL
Mice, Knockout
Viral Encephalitis
Mouse, Swiss

Related Feeds


Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.