Although the recent Zika virus (ZIKV) epidemic in the Americas and its link to birth defects have attracted a great deal of attention, much remains unknown about ZIKV disease epidemiology and ZIKV evolution, in part owing to a lack of genomic data. Here we address this gap in knowledge by using multiple sequencing approaches to generate 110 ZIKV genomes from clinical and mosquito samples from 10 countries and territories, greatly expanding the observed viral genetic diversity from this outbreak. We analysed the timing and patterns of introductions into distinct geographic regions; our phylogenetic evidence suggests rapid expansion of the outbreak in Brazil and multiple introductions of outbreak strains into Puerto Rico, Honduras, Colombia, other Caribbean islands, and the continental United States. We find that ZIKV circulated undetected in multiple regions for many months before the first locally transmitted cases were confirmed, highlighting the importance of surveillance of viral infections. We identify mutations with possible functional implications for ZIKV biology and pathogenesis, as well as those that might be relevant to the effectiveness of diagnostic tests.
Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007
The All-Species Living Tree project: a 16S rRNA-based phylogenetic tree of all sequenced type strains
HIV-1 evolution in gag and env is highly correlated but exhibits different relationships with viral load and the immune response
New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0
Improving the accuracy of demographic and molecular clock model comparison while accommodating phylogenetic uncertainty
Geneious Basic: an integrated and extendable desktop software platform for the organization and analysis of sequence data
Declining transition/transversion ratios through time reveal limitations to the accuracy of nucleotide substitution models
Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation
Coinfections of Zika and Chikungunya Viruses in Bahia, Brazil, Identified by Metagenomic Next-Generation Sequencing
Vital Signs: Update on Zika Virus-Associated Birth Defects and Evaluation of All U.S. Infants with Congenital Zika Virus Exposure - U.S. Zika Pregnancy Registry, 2016
Multiplex PCR method for MinION and Illumina sequencing of Zika and other virus genomes directly from clinical samples
Zika virus disease, microcephaly and Guillain-Barré syndrome in Colombia: epidemiological situation during 21 months of the Zika virus outbreak, 2015-2017
The influence of phylodynamic model specifications on parameter estimates of the Zika virus epidemic
Longitudinal Analysis of Antibody Cross-neutralization Following Zika Virus and Dengue Virus Infection in Asia and the Americas
The mosquito adulticidal Chromobacterium sp. Panama causes transgenerational impacts on fitness parameters and elicits xenobiotic gene responses
Infection via mosquito bite alters Zika virus tissue tropism and replication kinetics in rhesus macaques
Detection and phylogenetic characterization of arbovirus dual-infections among persons during a chikungunya fever outbreak, Haiti 2014
High Zika Virus Seroprevalence in Salvador, Northeastern Brazil Limits the Potential for Further Outbreaks
Aedes Anphevirus: an Insect-Specific Virus Distributed Worldwide in Aedes aegypti Mosquitoes That Has Complex Interplays with Wolbachia and Dengue Virus Infection in Cells
The Good, the Bad, and the Shocking: The Multiple Roles of Dengue Virus Nonstructural Protein 1 in Protection and Pathogenesis
Genome sequencing reveals coinfection by multiple chikungunya virus genotypes in a recent outbreak in Brazil
Zika Virus Causes Acute Infection and Inflammation in the Ovary of Mice Without Apparent Defects in Fertility
Discovery of Novel Crustacean and Cephalopod Flaviviruses: Insights into the Evolution and Circulation of Flaviviruses between Marine Invertebrate and Vertebrate Hosts
Phylogeography, phylodynamics and the recent outbreak of lineage 3 porcine reproductive and respiratory syndrome viruses in China
Inter- and intra-lineage genetic diversity of wild-type Zika viruses reveals both common and distinctive nucleotide variants and clusters of genomic diversity
High-Throughput Screening Identifies Mixed-Lineage Kinase 3 as a Key Host Regulatory Factor in Zika Virus Infection
Multiplex PCR method for MinION and Illumina sequencing of Zika and other virus genomes directly from clinical samples
Rapid and Highly Sensitive DNA Flow Technology Platform to Detect Tick-Borne Bacterial Pathogens in Clinical Samples
Zika circulation, congenital syndrome, and current guidelines: making sense of it all for the traveller
Real-time Metagenomic Analysis of Undiagnosed Fever Cases Unveils a Yellow Fever Outbreak in Edo State, Nigeria.
Genomic and Phylogenetic Analysis of Zika Virus Isolates from Asymptomatic Blood Donors in the United States and Puerto Rico, 2016.
Genomic epidemiology supports multiple introductions and cryptic transmission of Zika virus in Colombia
Multivariate time-series analysis of biomarkers from a dengue cohort offers new approaches for diagnosis and prognosis
Nanopore Targeted Sequencing for the Accurate and Comprehensive Detection of SARS-CoV-2 and Other Respiratory Viruses
Evolutionary Analysis of HIV-1 Pol Proteins Reveals Representative Residues for Viral Subtype Differentiation
Ontogeny of the B- and T-cell response in a primary Zika virus infection of a dengue-naïve individual during the 2016 outbreak in Miami, FL
Simultaneous Detection of Different Zika Virus Lineages via Molecular Computation in a Point-of-Care Assay
Emergence of the East-Central-South-African genotype of Chikungunya virus in Brazil and the city of Rio de Janeiro may have occurred years before surveillance detection
Specific detection and differentiation of tick-borne encephalitis and West Nile virus induced IgG antibodies in humans and horses
A consensus statement on birth defects surveillance, prevention, and care in Latin America and the Caribbean
Discrete viral E2 lysine residues and scavenger receptor MARCO are required for clearance of circulating alphaviruses
Novel genome sequences of cell-fusing agent virus allow comparison of virus phylogeny with the genetic structure of Aedes aegypti populations
Assessing Genome-Wide Diversity in European Hantaviruses through Sequence Capture from Natural Host Samples.
Evolution of Two Major Zika Virus Lineages: Implications for Pathology, Immune Response, and Vaccine Development
The epidemiological characteristics and molecular phylogeny of the dengue virus in Guangdong, China, 2015
Improved Immune Responses Against Zika Virus After Sequential Dengue and Zika Virus Infection in Humans
Deconvolution of pro- and antiviral genomic responses in Zika virus-infected and bystander macrophages
Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes.
High-Quality Resolution of the Outbreak-Related Zika Virus Genome and Discovery of New Viruses Using Ion Torrent-Based Metatranscriptomics.
Multiple approaches for massively parallel sequencing of SARS-CoV-2 genomes directly from clinical samples
Laboratory Evaluation of Commercially Available Platforms to Detect West Nile and Zika Viruses From Honey Cards
Assessment of metagenomic Nanopore and Illumina sequencing for recovering whole genome sequences of chikungunya and dengue viruses directly from clinical samples
Spatial diffusion of the 2015-2016 Zika, dengue and chikungunya epidemics in Rio de Janeiro Municipality, Brazil
Phylogenetic surveillance of travel-related Zika virus infections through whole-genome sequencing methods
Impression Cytology Is a Non-invasive and Effective Method for Ocular Cell Retrieval of Zika Infected Babies: Perspectives in OMIC Studies
Antibiotic fidaxomicin is an RdRp inhibitor as a potential new therapeutic agent against Zika virus.
Audiological Findings in Children Suspected to Have Been Exposed to the Zika Virus in the Intrauterine Period.
Evolutionary trajectory of fish Piscine novirhabdovirus (=Viral Hemorrhagic Septicemia Virus) across its Laurentian Great Lakes history: Spatial and temporal diversification
Tracing the origin of the NS1 A188V substitution responsible for recent enhancement of Zika virus Asian genotype infectivity
Sofosbuvir protects Zika virus-infected mice from mortality, preventing short- and long-term sequelae
Large-scale analysis of B-cell epitopes of envelope: Implications for Zika vaccine and immunotherapeutic development
Peptide arrays incubated with three collections of human sera from patients infected with mosquito-borne viruses
Another piece of the Zika puzzle: assessing the associated factors to microcephaly in a systematic review and meta-analysis
Multiplexed kit based on Luminex technology and achievements in synthetic biology discriminates Zika, chikungunya, and dengue viruses in mosquitoes
Localized Outbreaks of Epidemic Polyarthritis among Military Personnel Caused by Different Sublineages of Ross River Virus, Northeastern Australia, 2016-2017
Next Generation Sequencing and Bioinformatics Methodologies for Infectious Disease Research and Public Health: Approaches, Applications, and Considerations for Development of Laboratory Capacity.
Two Sides of a Coin: a Zika Virus Mutation Selected in Pregnant Rhesus Macaques Promotes Fetal Infection in Mice but at a Cost of Reduced Fitness in Nonpregnant Macaques and Diminished Transmissibility by Vectors.
Zika virus infection of first trimester trophoblast cells affects cell migration, metabolism and immune homeostasis control
Culture-free genome-wide locus sequence typing (GLST) provides new perspectives on Trypanosoma cruzi dispersal and infection complexity.
Peptide-Based Subunit Vaccine Design of T- and B-Cells Multi-Epitopes against Zika Virus Using Immunoinformatics Approaches
Influence of directional positive Darwinian selection-driven evolution on arboviruses Dengue and Zika virulence and pathogenesis
Update on the Transmission of Zika Virus Through Breast Milk and Breastfeeding: A Systematic Review of the Evidence.
Detection and discrimination of multiple strains of Zika virus by reverse transcription-loop-mediated isothermal amplification
Divergent Mutational Landscapes of Consensus and Minority Genotypes of West Nile Virus Demonstrate Host and Gene-Specific Evolutionary Pressures
New Insights on the Zika Virus Arrival in the Americas and Spatiotemporal Reconstruction of the Epidemic Dynamics in Brazil.
What Will Happen to Biomedical Research in Low-and-Middle Income Countries in the PostCOVID-19 World?
Urban health nexus with coronavirus disease 2019 (COVID-19) preparedness and response in Africa: Rapid scoping review of the early evidence.
A Bacterially-Expressed Recombinant Envelope Protein from Usutu Virus Induces Neutralizing Antibodies in Rabbits.
Support for vector control strategies in the United States during the Zika outbreak in 2016: The role of risk perception, knowledge, and confidence in government
COVID-19, Chikungunya, Dengue and Zika Diseases: An Analytical Platform Based on MALDI-TOF MS, IR Spectroscopy and RT-qPCR for Accurate Diagnosis and Accelerate Epidemics Control.
Common Dysregulation of Innate Immunity Pathways in Human Primary Astrocytes Infected With Chikungunya, Mayaro, Oropouche, and Zika Viruses.
What determines city's resilience against epidemic outbreak: evidence from China's COVID-19 experience.
Recent advances in understanding the adaptive immune response to Zika virus and the effect of previous flavivirus exposure
Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.