Zika virus evolution and spread in the Americas

Hayden C MetskyPardis C Sabeti


Although the recent Zika virus (ZIKV) epidemic in the Americas and its link to birth defects have attracted a great deal of attention, much remains unknown about ZIKV disease epidemiology and ZIKV evolution, in part owing to a lack of genomic data. Here we address this gap in knowledge by using multiple sequencing approaches to generate 110 ZIKV genomes from clinical and mosquito samples from 10 countries and territories, greatly expanding the observed viral genetic diversity from this outbreak. We analysed the timing and patterns of introductions into distinct geographic regions; our phylogenetic evidence suggests rapid expansion of the outbreak in Brazil and multiple introductions of outbreak strains into Puerto Rico, Honduras, Colombia, other Caribbean islands, and the continental United States. We find that ZIKV circulated undetected in multiple regions for many months before the first locally transmitted cases were confirmed, highlighting the importance of surveillance of viral infections. We identify mutations with possible functional implications for ZIKV biology and pathogenesis, as well as those that might be relevant to the effectiveness of diagnostic tests.


Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S Henikoff, J G Henikoff
May 1, 1996·Journal of Molecular Evolution·Z Yang
Feb 11, 2005·Molecular Biology and Evolution·Alexei J DrummondOliver G Pybus
Sep 24, 2005·Molecular Biology and Evolution·Beth ShapiroAlexei J Drummond
May 11, 2006·PLoS Biology·Alexei J DrummondAndrew Rambaut
Dec 12, 2007·PLoS Pathogens·Konstantin A TsetsarkinStephen Higgs
Aug 5, 2008·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Oumar FayeAmadou Alpha Sall
Aug 6, 2008·Emerging Infectious Diseases·Robert S LanciottiMark R Duffy
Aug 12, 2008·Systematic and Applied Microbiology·Pablo YarzaRamon Rosselló-Móra
Oct 23, 2008·Nucleic Acids Research·Eric W SayersJian Ye
Oct 30, 2008·Nucleic Acids Research·Cristina AurrecoecheaHaiming Wang
Jun 10, 2009·Bioinformatics·Heng Li1000 Genome Project Data Processing Subgroup
Oct 14, 2009·Clinical Microbiology Reviews·Byron E E MartinaAlbert D M E Osterhaus
Nov 6, 2009·Journal of Virology·Amadou Alpha SallE C Holmes
Oct 5, 2010·Molecular Biology and Evolution·Beth ShapiroAndrew Rambaut
May 17, 2011·Nature Biotechnology·Manfred G GrabherrAviv Regev
Mar 1, 2012·Molecular Biology and Evolution·Alexei J DrummondAndrew Rambaut
Jul 17, 2012·Bioinformatics·Doug HyattEdward C Uberbacher
Jul 25, 2012·Journal of Medical Virology·Michelle N D BalmJulian W Tang
Oct 13, 2012·Bioinformatics·Limin FuWeizhong Li
Oct 24, 2012·Molecular Biology and Evolution·Guy BaelePhilippe Lemey
Jan 19, 2013·Molecular Biology and Evolution·Kazutaka Katoh, Daron M Standley
May 15, 2013·PloS One·Christian Julian Villabona-ArenasMauricio L Nogueira
Mar 4, 2014·Genome Biology·Derrick E Wood, Steven L Salzberg
Jun 20, 2014·PLoS Currents·Alyssa T PykeRichard Gair
Oct 30, 2014·The New England Journal of Medicine·John S SchieffelinWHO Clinical Response Team
Nov 28, 2014·Nucleic Acids Research·J Rodney BristerOlga Blinkova
Dec 23, 2014·Emerging Infectious Diseases·Ann-Claire GourinatMyrielle Dupont-Rouzeyrol
Feb 17, 2015·Virus Research·Margo A Brinton, Mausumi Basu
May 16, 2015·BMC Medicine·Marcio NunesPedro Fernando da Costa Vasconcelos
Nov 22, 2015·Nucleic Acids Research·Karen ClarkEric W Sayers
Nov 29, 2015·Nucleic Acids Research·NCBI Resource Coordinators
Jan 14, 2016·The New England Journal of Medicine·Anthony S Fauci, David M Morens
Mar 26, 2016·Science·Nuno R FariaPedro F C Vasconcelos
Dec 21, 2016·Bulletin of the World Health Organization·Victor M CormanJan Felix Drexler
Feb 15, 2017·The New England Journal of Medicine·Gabriela Paz-BaileyTyler M Sharp
Mar 3, 2017·Bulletin of the World Health Organization·T JaenischErnesto T A Marques
Apr 7, 2017·MMWR. Morbidity and Mortality Weekly Report·Megan R ReynoldsU.S. Zika Pregnancy Registry Collaboration
Nov 10, 2017·Archives of public health = Archives belges de santé publique·Nelson MéndezGerman Arrieta


Nov 25, 2017·Birth Defects Research·Adrienne T HoytAngela E Scheuerle
Oct 20, 2017·Human Molecular Genetics·Pinar MesciAlysson R Muotri
Dec 22, 2017·The Journal of Infectious Diseases·Laura S MuñozNeuroviruses Emerging in the Americas Study
Feb 6, 2018·Emerging Infectious Diseases·John-Paul MutebiJoan L Kenney
Feb 24, 2018·International Journal of Environmental Research and Public Health·Claude RothAnavaj Sakuntabhai
Feb 7, 2018·Frontiers in Microbiology·Raj K SinghRubén Bueno-Marí
Nov 13, 2017·Science and Engineering Ethics·Pawel Sobkowicz
Sep 28, 2017·Emerging Infectious Diseases·Sonia R Lambert PassosYara H M Hökerberg
Apr 28, 2018·Science·Cameron MyhrvoldPardis C Sabeti
Aug 6, 2018·Applied Microbiology and Biotechnology·Tiphaine C MartinMario Falchi
Aug 4, 2018·Reviews in Medical Virology·Vivian I Avelino-Silva, Esper G Kallas
Aug 25, 2018·PLoS Biology·Jimena Barbeito-AndrésPatrícia Pestana Garcez
Oct 3, 2018·International Journal of Environmental Research and Public Health·Jolyon M MedlockSteve Leach
Oct 13, 2018·Critical Care Medicine·Thomas J PapadimosJudy E Davidson
Nov 9, 2018·The Pediatric Infectious Disease Journal·Cheng-Ying HoAileen Y Chang
Dec 5, 2018·Electrophoresis·Roxanne R ZascavageJohn V Planz
Jan 9, 2019·Nature Reviews. Microbiology·Zhong-Yu LiuCheng-Feng Qin
Jan 30, 2018·Cellular & Molecular Immunology·Yhojan RodríguezJuan-Manuel Anaya
Jan 31, 2019·PLoS Neglected Tropical Diseases·Caroline S de FreitasThiago Moreno L Souza
Jan 17, 2019·Non-coding RNA·Nkerorema Djodji DamasTroels K H Scheel
Jan 29, 2019·Molecular Biology and Evolution·Qiqing TaoSudhir Kumar
May 26, 2017·Nature·Michael Worobey
Mar 17, 2019·American Journal of Epidemiology·Joseph A Lewnard, Arthur L Reingold
Apr 19, 2019·PLoS Pathogens·Thomas LangerakMarion P G Koopmans
May 17, 2019·PLoS Neglected Tropical Diseases·Lais Ceschini MachadoGabriel Luz Wallau
May 8, 2019·The Journal of Infectious Diseases·Elizabeth A CaineKelle H Moley
Oct 11, 2019·Archives of Virology·Lucia P Barzilai, Carlos G Schrago
Nov 12, 2019·The Journal of Infectious Diseases·Simon PollettNathan D Grubaugh
Sep 25, 2019·Microorganisms·Eleonora CiminiChiara Agrati
Sep 6, 2019·Proceedings of the National Academy of Sciences of the United States of America·Jinn-Jy LinWen-Hsiung Li
Nov 28, 2019·Journal of Computer-aided Molecular Design·Stephen J BarigyeJuan A Castillo-Garit
Jul 16, 2019·Current Opinion in Infectious Diseases·Lin H Chen, Mary E Wilson
Feb 27, 2020·Molecular Biology and Evolution·Mandev S GillGuy Baele
Feb 12, 2020·The American Journal of Tropical Medicine and Hygiene·Felipe Lopes AssisMaria Rios
Sep 22, 2019·Nature Communications·Erick X Pérez-GuzmánCarlos A Sariol
Jun 17, 2020·PLoS Neglected Tropical Diseases·Baptiste VaseyNorma Blumenfeld deBosch
Aug 5, 2020·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Mateus V ThomazellaDennis A Bertolini
Aug 22, 2020·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Andre L Lima DinizLuciano A Favorito
Aug 10, 2017·Journal of Medical Virology·Fabián AldunateJuan Cristina
May 4, 2018·Molecular Biology and Evolution·Seth N RedmondDaniel E Neafsey
Aug 31, 2018·Nature·Theodore C Pierson, Michael S Diamond
Oct 19, 2018·Emerging Infectious Diseases·Edson DelatorreGonzalo Bello
Apr 16, 2019·Transboundary and Emerging Diseases·Alexandra RockstrohSebastian Ulbert
May 17, 2019·Revista Panamericana De Salud Pública = Pan American Journal of Public Health·Ignacio ZarantePablo Durán
Jun 6, 2020·Tropical Medicine and Infectious Disease·Elysse N Grossi-Soyster, A Desiree LaBeaud
Jul 15, 2018·BMC Genomics·Hyeji LeeYong-Hak Kim
Sep 13, 2018·Proceedings of the National Academy of Sciences of the United States of America·Aaron F CarlinChristopher K Glass
Oct 28, 2018·Scientific Reports·Susmita ShrivastavaBrett E Pickett
Feb 6, 2019·Nature Biotechnology·Hayden C MetskyChristian B Matranga
Dec 14, 2018·Frontiers in Microbiology·Maxime Gaudin, Christelle Desnues
Sep 25, 2019·Viruses·Pietro ScaturroAndreas Pichlmair
Mar 5, 2020·Revista Do Instituto De Medicina Tropical De São Paulo·Fabrício MorelliMarcia Edilaine Lopes Consolaro
May 6, 2020·Nature Microbiology·Theodore C Pierson, Michael S Diamond
Feb 21, 2018·Journal of Medical Entomology·Kristen L BurkhalterBarry W Alto
Dec 29, 2017·Immunity, Inflammation and Disease·Jessica Badolato-CorrêaLuzia Maria de-Oliveira-Pinto
Dec 20, 2018·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Liana E KafetzopoulouSteven T Pullan
Apr 5, 2019·Journal of Virology·Derek L CarbaughHelen M Lazear
Jan 23, 2019·Emerging Infectious Diseases·Fernando A BozzaJan Felix Drexler
Jun 23, 2020·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Armanda de Oliveira Pache de FariaClaudete Aparecida Araújo Cardoso
Aug 27, 2017·Scientific Reports·André C FerreiraThiago Moreno L Souza
Feb 9, 2018·Expert Review of Anti-infective Therapy·Antoni Soriano-ArandesFederico Martinón-Torres
Jul 10, 2019·Annual Review of Neuroscience·Kimberly M ChristianGuo-Li Ming
Mar 24, 2020·F1000Research·Maria Del Pilar Martinez ViedmaBrett E Pickett
Nov 30, 2019·Frontiers in Public Health·Stephanie M LimByron E E Martina
Nov 8, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Marcos Vinicius da Silva PoneTallita de Oliveira Gomes da Silva
Dec 1, 2017·Memórias do Instituto Oswaldo Cruz·Gabriela Bastos CabralLuís Fernando de Macedo Brígido
Jun 4, 2020·Anais Da Academia Brasileira De Ciências·Denny M CárdenasKarl A Ciuoderis
Sep 2, 2019·Molecular Phylogenetics and Evolution·Ricardo Durães-CarvalhoErnesto T A Marques
Feb 4, 2021·Genetics and Molecular Biology·Joel Henrique EllwangerJosé Artur Bogo Chies
Feb 10, 2021·Medicinal Research Reviews·Xianlong ZhangTony D James
Feb 12, 2021·Transactions of the Royal Society of Tropical Medicine and Hygiene·Sabrina L LiLauren Gardner
Oct 24, 2020·Open Forum Infectious Diseases·Erica NormandinAnne Piantadosi
Dec 31, 2020·Viruses·Stephen D Carro, Sara Cherry
Jan 8, 2021·Virus Evolution·Katherine E E JohnsonKenneth A Stapleford
Jan 12, 2021·Current Tropical Medicine Reports·Gustavo Fontecha, Ana L Sánchez
Oct 29, 2017·Current Opinion in Virology·Derek J Platt, Jonathan J Miner
Apr 1, 2021·Frontiers in Cellular and Infection Microbiology·Victor Emmanuel Viana GeddesRenato Santana de Aguiar

Related Concepts

Zika Virus Disease (Disorder)
Zika virus (organism)
Mosquito Vectors
Disease Outbreaks
Viral Genome
Genetic Epidemiology

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Related Papers

Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin
Sebastian Maurer-StrohRaymond Tp Lin
© 2021 Meta ULC. All rights reserved