Zika virus-induced acute myelitis and motor deficits in adult interferon αβ/γ receptor knockout mice

Journal of Neurovirology
Katherine ZukorJohn D Morrey

Abstract

Zika virus (ZIKV) has received widespread attention because of its effect on the developing fetus. It is becoming apparent, however, that severe neurological sequelae, such as Guillian-Barrë syndrome (GBS), myelitis, encephalitis, and seizures can occur after infection of adults. This study demonstrates that a contemporary strain of ZIKV can widely infect astrocytes and neurons in the brain and spinal cord of adult, interferon α/β receptor knockout mice (AG129 strain) and cause progressive hindlimb paralysis, as well as severe seizure-like activity during the acute phase of disease. The severity of hindlimb motor deficits correlated with increased numbers of ZIKV-infected lumbosacral spinal motor neurons and decreased numbers of spinal motor neurons. Electrophysiological compound muscle action potential (CMAP) amplitudes in response to stimulation of the lumbosacral spinal cord were reduced when obvious motor deficits were present. ZIKV immunoreactivity was high, intense, and obvious in tissue sections of the brain and spinal cord. Infection in the brain and spinal cord was also associated with astrogliosis as well as T cell and neutrophil infiltration. CMAP and histological analysis indicated that peripheral nerve and muscle f...Continue Reading

References

Aug 12, 1981·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·S McHanwell, T J Biscoe
Aug 1, 1995·Journal of Virology·M F van den BroekR M Zinkernagel
Aug 2, 2003·Emerging Infectious Diseases·James J SejvarLyle R Petersen
Sep 1, 1952·Transactions of the Royal Society of Tropical Medicine and Hygiene·G W A DICK
Dec 4, 2003·Journal of Virology·Bimmi ShresthaMichael S Diamond
Jun 16, 2004·Antiviral Research·John D MorreyLawrence M Blatt
Mar 5, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stan T NakanishiMartin J Pinter
Dec 13, 2006·The European Journal of Neuroscience·K B MarquesA L R Oliveira
Oct 18, 2007·Proceedings of the National Academy of Sciences of the United States of America·Melanie A SamuelMichael S Diamond
Aug 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Erin E McCandlessRobyn S Klein
Oct 12, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Katherine A ZukorShannon J Odelberg
Nov 6, 2010·The Journal of Infectious Diseases·Fengwei BaiRuth R Montgomery
May 20, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aki ItohTakayuki Itoh
Jul 28, 2012·Nature Neuroscience·Shalina S Ousman, Paul Kubes
Aug 30, 2012·Nature Methods·Caroline A SchneiderKevin W Eliceiri
Oct 12, 2012·PLoS Pathogens·Sebastian AguirreAna Fernandez-Sesma
Dec 19, 2012·NeuroImage·Megan HarrisonCharles Watson
Feb 3, 2015·Trends in Microbiology·Matthew P Taylor, Lynn W Enquist
Oct 28, 2015·Nature Neuroscience·Won-Suk ChungBeth Stevens
Nov 20, 2015·Emerging Infectious Diseases·Cristiane W CardosoGuilherme S Ribeiro
Jan 29, 2016·MMWR. Morbidity and Mortality Weekly Report·Lavinia Schuler-FacciniUNKNOWN Brazilian Medical Genetics Society–Zika Embryopathy Task Force
Feb 8, 2016·Lancet·Udani Samarasekera, Marcia Triunfol
Mar 8, 2016·Lancet·Sylvie MécharlesAnnie Lannuzel
Mar 10, 2016·The New England Journal of Medicine·Guillaume CarteauxArmand Mekontso Dessap
Mar 30, 2016·The American Journal of Tropical Medicine and Hygiene·Shannan L RossiScott C Weaver
Apr 14, 2016·Cell Host & Microbe·Helen M LazearMichael S Diamond
Apr 20, 2016·PLoS Neglected Tropical Diseases·Matthew T AliotaJorge E Osorio
Apr 27, 2016·Lancet·Patrícia BrasilTom Solomon
Aug 16, 2016·Journal of Neuroinfectious Diseases·Isaac H SolomonRebecca D Folkerth
Aug 30, 2016·Cellular & Molecular Immunology·Derek Dc IrelandDaniela Verthelyi
Sep 2, 2016·MMWR. Morbidity and Mortality Weekly Report·Emilio DirlikovBrenda Rivera-Garcia
Sep 7, 2016·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Cristiane N SoaresTom Solomon
Sep 13, 2016·Emerging Infectious Diseases·Emanuele NicastriGiuseppe Ippolito
Oct 28, 2016·Seizure : the Journal of the British Epilepsy Association·Ali A Asadi-Pooya

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Citations

Nov 7, 2019·Frontiers in Cellular Neuroscience·Jessica BellmannJared Sterneckert
Jul 7, 2018·Molecular Neurobiology·Luca BartoliniWilliam D Gaillard
Apr 12, 2019·Frontiers in Cellular Neuroscience·Christian AlfanoLaurent Nguyen
Oct 28, 2019·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ilker Kudret SariyerKamel Khalili
May 6, 2021·International Journal of Molecular Sciences·Ashley A StegelmeierKhalil Karimi
Jun 3, 2021·Cells·Abenaya Muralidharan, St Patrick Reid

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Datasets Mentioned

BETA
KU501215
KX087101
PRVABC59

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electron microscopy

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Prism
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