Zika virus infection in chemosensory cells.

Journal of Neurovirology
Mehmet Hakan OzdenerIlker Kudret Sariyer

Abstract

Zika virus (ZIKV) is an emerging virus belonging to the genus Flavivirus. ZIKV infection is a significant health concern, with increasing numbers of reports of microcephaly cases in fetuses and Guillain-Barré syndrome (GBS) in adults. Interestingly, chemosensory disturbances are also reported as one of the manifestations of GBS. ZIKV infects several human tissues and cell types in vitro and in vivo. However, there is no study demonstrating ZIKV infection and replication in chemosensory cells, including olfactory and taste cells. Taste papilla and olfactory cells are chemosensory receptor cells with unique histological, molecular, and physiological characteristics. Here we examined ZIKV infection (PRVABC59) in cultured human olfactory epithelial cells (hOECs) and fungiform taste papilla (HBO) cells in vitro, as well as in vivo mouse taste and olfactory epithelial and olfactory bulb tissues. Interestingly, while HBO cells showed resistance to ZIKV replication, hOECs were highly susceptible for ZIKV infection and replication. Further, we demonstrated the presence of ZIKV particles and expression of viral proteins in olfactory epithelium, as well as in olfactory bulb, but not in taste papillae, of immunocompromised mice (ifnar/-) i...Continue Reading

References

Jan 1, 1971·Archiv für die gesamte Virusforschung·T M BellH K Narang
Nov 1, 1965·The Journal of Cell Biology·L M Beidler, R L Smallman
Dec 22, 1998·European Journal of Cell Biology·P RösslerH Breer
Dec 5, 2000·Journal of Neuroscience Research·G GomezD Restrepo
Sep 1, 1952·Transactions of the Royal Society of Tropical Medicine and Hygiene·G W A DICKA J HADDOW
Mar 1, 1954·Transactions of the Royal Society of Tropical Medicine and Hygiene·F N MACNAMARA
Feb 3, 2006·Chemical Senses·Hakan OzdenerNancy E Rawson
Oct 5, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hong WangLiquan Huang
Aug 6, 2008·Emerging Infectious Diseases·Robert S LanciottiMark R Duffy
Apr 8, 2011·Chemical Senses·Mehmet Hakan OzdenerNancy E Rawson
May 31, 2012·Journal of Visualized Experiments : JoVE·Hakan OzdenerNancy E Rawson
Oct 26, 2012·Methods in Molecular Biology·Nancy E Rawson, Mehmet Hakan Ozdener
Apr 23, 2013·Cell Host & Microbe·Orkide O KoyuncuLynn W Enquist
Jan 24, 2015·Mediators of Inflammation·Kishan Kumar Nyati, Kashi Nath Prasad
Jun 19, 2015·Journal of Virology·Rodolphe HamelDorothée Missé
Sep 25, 2015·Emerging Infectious Diseases·Gubio S CamposSilvia I Sardi
Jan 19, 2016·Lancet·Isaac I BogochKamran Khan
Feb 11, 2016·The New England Journal of Medicine·Jernej MlakarTatjana Avšič Županc
Apr 9, 2016·ACS Chemical Neuroscience·Douglas M DurrantRobyn S Klein
Apr 19, 2016·Emerging Infectious Diseases·Robert S LanciottiLeticia Del Carmen Castillo Signor
Jun 2, 2016·Cell Host & Microbe·Kendra M QuickeMehul S Suthar
Dec 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·Hanna RetallackJoseph L DeRisi
Feb 6, 2017·Journal of Virology·Thomas E Morrison, Michael S Diamond
Feb 10, 2017·Cell Host & Microbe·Jonathan J Miner, Michael S Diamond
Mar 30, 2018·Journal of Neurovirology·Olivier SimonMyrielle Dupont-Rouzeyrol

❮ Previous
Next ❯

Citations

Jul 15, 2020·Journal of Child Neurology·Alison Christy

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic

Software Mentioned

Adobe Photoshop

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.