Zika Virus Infects Newborn Monocytes Without Triggering a Substantial Cytokine Response

The Journal of Infectious Diseases
Fabio Seiti Yamada YoshikawaMaria Notomi Sato

Abstract

Zika virus (ZIKV) is a clinically important flavivirus that can cause neurological disturbances in newborns. Here, we investigated comparatively the outcome of in vitro infection of newborn monocytes by ZIKV. We observed that neonatal cells show defective production of interleukin 1β, interleukin 10, and monocyte chemoattractant protein 1 in response to ZIKV, although they were as efficient as adult cells in supporting viral infection. Although CLEC5A is a classical flavivirus immune receptor, it is not essential to the cytokine response, but it regulates the viral load only in adult cells. Greater expression of viral entry receptors may create a favorable environment for viral invasion in neonatal monocytes. We are the first to suggest a role for CLEC5A in human monocyte infectivity and to show that newborn monocytes are interesting targets in ZIKV pathogenesis, owing to their ability to carry the virus with only a partial triggering of the immune response, creating a potentially favorable environment for virus-related pathologies in young individuals.

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Citations

Jul 28, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andrea Kovacs
Sep 29, 2019·Nature Communications·Nilda Vanesa Ayala-NunezRaphael Gaudin
Jun 5, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Clayton W WinklerKarin E Peterson
Apr 4, 2021·Vaccines·Judith Estévez-HerreraAgustín Valenzuela-Fernández
Jun 3, 2021·International Journal of Molecular Sciences·Sarah Cunningham, Holger Hackstein
May 30, 2021·Virology·Utkarsh BhardwajSunit K Singh

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