Zika virus RNA and IgM persistence in blood compartments and body fluids: a prospective observational study

The Lancet Infectious Diseases
Mars StoneNHLBI Recipient Epidemiology Donor Evaluation Study REDS-III Program

Abstract

Characterisation of the dynamics of Zika virus persistence following acute infection is needed to inform blood donor and diagnostic testing policies and understand the natural history of Zika virus infection. We aimed to characterise the natural history, persistence, and clinical outcomes of Zika virus infection through a prospective study in initially asymptomatic Zika virus RNA-positive blood donors. Zika virus-infected blood donors identified through Zika virus nucleic acid amplification test (NAAT) screening at three blood collection organisations in the USA were enrolled into a 1-year follow-up study, with blood and body fluid samples and detailed symptom data collected at up to seven visits. All samples were tested for Zika virus RNA by real-time PCR (rtPCR); follow-up plasma, whole blood, and urine were also tested by replicate NAAT. Plasma was tested for flavivirus-specific IgM and IgG by ELISA. Zika virus RNA persistence for each assay or sample type and plasma antibody persistence from estimated date of plasma NAAT-detectable infection were calculated from follow-up data using survival statistical methods. Between July 6, 2016 and March 7, 2017, we enrolled 53 participants. From the estimated date of plasma NAAT-detec...Continue Reading

Citations

Aug 10, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael P Busch, Mars Stone
Nov 1, 2020·Pathogens·Sophie MasmejanDavid Baud
Feb 6, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael P Busch, Mars Stone
Apr 27, 2021·Emerging Infectious Diseases·Asher Y RosingerCarrie K Shapiro-Mendoza
Jun 11, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mars StoneUNKNOWN NHLBI Recipient Epidemiology and Donor Evaluation Study-IV-Pediatric (REDS-IV-P)
Aug 29, 2021·Viruses·Joseph R BiggsJulius Clemence R Hafalla

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