Zika Virus-Specific IgY Results Are Therapeutic Following a Lethal Zika Virus Challenge without Inducing Antibody-Dependent Enhancement

Viruses
Kyle L O'DonnellDavid S Bradley

Abstract

The Zika virus (ZIKV) is a newly emerged pathogen in the Western hemisphere. It was declared a global health emergency by the World Health Organization in 2016. There have been 223,477 confirmed cases, including 3720 congenital syndrome cases since 2015. ZIKV infection symptoms range from asymptomatic to Gullain⁻Barré syndrome and extensive neuropathology in infected fetuses. Passive and active vaccines have been unsuccessful in the protection from or the treatment of flaviviral infections due to antibody-dependent enhancement (ADE). ADE causes an increased viral load due to an increased monocyte opsonization by non-neutralizing, low-avidity antibodies from a previous dengue virus (DENV) infection or from a previous exposure to ZIKV. We have previously demonstrated that polyclonal avian IgY generated against whole-killed DENV-2 ameliorates DENV infection in mice while not inducing ADE. This is likely due to the inability of the Fc portion of IgY to bind to mammalian Fc receptors. We have shown here that ZIKV oligoclonal IgY is able to neutralize the virus in vitro and in IFNAR-/- mice. The concentration of ZIKV-specific IgY yielding 50% neutralization (NT50) was 25 µg/mL. The exposure of the ZIKV, prior to culture with ZIKV-spe...Continue Reading

References

Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R ParvariI Schechter
Oct 1, 1993·Poultry Science·Anders LarssonP O Forsberg
Apr 2, 1998·Current Opinion in Immunology·P D Stahl, R A Ezekowitz
Sep 1, 1952·Transactions of the Royal Society of Tropical Medicine and Hygiene·G W A DICKA J HADDOW
Oct 13, 2005·Veterinary Immunology and Immunopathology·Anne-Marie TorchéMarie-Frédérique Le Potier
Mar 18, 2006·The Journal of Infectious Diseases·Panisadee AvirutnanPrida Malasit
Jun 12, 2010·Molecular Immunology·Kirstin M HeutinckAjda T Rowshani
Apr 17, 2014·The Journal of Biological Chemistry·Paul J ConroyJames C Whisstock
Apr 20, 2016·Nature·Victor A KostyuchenkoShee-Mei Lok
Apr 27, 2016·Lancet·Patrícia BrasilTom Solomon
Jun 30, 2016·BMJ : British Medical Journal·Owen Dyer
Jun 30, 2016·Lancet·Leonelo E Bautista, Ajay K Sethi
Jun 30, 2016·Nature·Rafael A LaroccaDan H Barouch
Jul 4, 2016·Lancet·Roosecelis Brasil MartinesSherif R Zaki
Sep 24, 2016·PLoS Currents·Anu Susan Charles, Rebecca C Christofferson
Nov 5, 2016·Frontiers in Microbiology·Álvaro FajardoPilar Moreno
Mar 23, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jucille do Amaral MenesesLindomar José Pena
Apr 7, 2017·JAMA : the Journal of the American Medical Association·Daniel LuceySabrina Sholts
May 13, 2017·Journal of Medical Entomology·Kyle L O'DonnellJefferson A Vaughan
Aug 22, 2017·Frontiers in Microbiology·Ashok MunjalSunil K Joshi
Sep 15, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shu-Wen WanYee-Shin Lin
Oct 6, 2017·Science Translational Medicine·Diogo M MagnaniDavid I Watkins
Nov 4, 2017·Science·Leah C KatzelnickEva Harris

Citations

Sep 3, 2020·Vaccines·José M Pérez de la LastraAntonio Morales-delaNuez

Related Concepts

Dengue Fever
Dengue Virus
Fetus
Flavivirus
Flucytosine
Guillain-Barre Syndrome
Immunoglobulin G
Laboratory mice
Fc Receptor
Vaccines

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