Zika Virus Vaccines: Challenges and Perspectives

Vaccines
Raquel das Neves AlmeidaGary P Kobinger

Abstract

Zika virus is an arbovirus that has rapidly spread within the Americas since 2014, presenting a variety of clinical manifestations and neurological complications resulting in congenital malformation, microcephaly, and possibly, in male infertility. These significant clinical manifestations have led investigators to develop several candidate vaccines specific to Zika virus. In this review we describe relevant targets for the development of vaccines specific for Zika virus, the development status of various vaccine candidates and their different platforms, as well as their clinical progression.

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Citations

Dec 14, 2018·International Journal of Molecular Sciences·Po-Yuan Ke
Apr 10, 2019·Tropical Medicine and Infectious Disease·In-Jeong KimJr-Shiuan Lin
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Methods Mentioned

BETA
glycosylation

Clinical Trials Mentioned

NCT02996890
NCT03008122
NCT02963909
NCT02952833
NCT02937233
NCT02840487
NCT02809443
NCT02887482
NCT03014089

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